ArticleAnalytical chemistry2010
High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Potential Usefulness of Urinary Hepcidin Measurement for Iron Deficiency Anemia in Female Athletes.European journal of sport science · 2026Article
- Determination of Heavy Metal Ions and Organic Pollutants in Water Samples Using Ionic Liquids and Ionic Liquid-Modified Sorbents.Journal of analytical methods in chemistry · 2019Review
- Laboratory use of hepcidin in renal transplant recipients.Biochemia medica · 2016Review
- Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.The Journal of biological chemistry · 2015Review
- Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids.Nanomedicine : nanotechnology, biology, and medicine · 2014Article
- Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by a robust LC-MS/MS method.Clinica chimica acta; international journal of clinical chemistry · 2011Article
- A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.Blood · 2011Article
- Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Levels of the peptide hormone hepcidin negatively correlate with systemic iron status and are increased in disorders in which iron metabolism is secondarily disregulated, such as the anemia of chronic disease. Consequently, the ability to measure hepcidin in the clinical setting may have diagnostic value for a broad range of indications. We describe a novel quantitative matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry assay for hepcidin in human urine which involves (i) direct enrichment from minute volumes (5 microL) of minimally treated urine on the surface of a functionalized chip, (ii) quantification by the use of a stable isotope labeled internal standard, and (iii) analysis by MALDI-TOF. Performance features include a wide linear range (1-1000 nM; LOQ 2.5 nM), high accuracy (90-110% recovery) and precision (intraday CV 12.11%; interday CV 13.21%), and a strong correlation upon interlaboratory cross validation with an existing immunoassay. The assay is simple, accurate, and efficient, and the high-throughput performance features of the assay make large-scale clinical research studies feasible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.