ArticleWorld journal of gastroenterology2010
Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model: a comparative study.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B: a meta-analysis of diagnostic test.Oncotarget · 2017Pooled it
- Pooled it
- The diagnostic value of the FIB-4 index for staging hepatitis B-related fibrosis: a meta-analysis.PloS one · 2014Pooled it
- Diagnostic accuracy of the aspartate aminotransferase-to-platelet ratio index for the prediction of hepatitis B-related fibrosis: a leading meta-analysis.BMC gastroenterology · 2012Pooled it
- Integrated clinicopathological model versus TNM for predicting survival in resected hepatocellular carcinoma: a retrospective cohort study.BMC gastroenterology · 2026Article
- A New Assessment of Two Transferase-Based Liver Enzymes in Low- and High-Fibrosis Patients Chronically Infected with Hepatitis B Virus: A Meta-Analysis and Pilot Study.Journal of clinical medicine · 2024Article
- The adverse characteristics of hepatocellular carcinoma in the non-cirrhotic liver disproportionately disadvantage Black patients.Cancer medicine · 2024Article
- Evaluation of muscle strength and quality in North African patients with chronic hepatitis B: A pilot case control study.The Libyan journal of medicine · 2023Article
- A Generic Nomogram Predicting the Stage of Liver Fibrosis Based on Serum Biochemical Indicators Among Chronic Hepatitis B Patients.Frontiers in medicine · 2021Article
- Artificial Neural Network Model for Liver Cirrhosis Diagnosis in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.Therapeutics and clinical risk management · 2020Article
- Characteristics and outcomes of antiretroviral-treated HIV-HBV co-infected patients in Canada?BMC infectious diseases · 2019Article
- Performance of common imaging techniquesWorld journal of clinical cases · 2019Article
- Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.Annals of translational medicine · 2017Review
- Noninvasive models for assessment of liver fibrosis in patients with chronic hepatitis B virus infection.World journal of gastroenterology · 2016Review
- Can Serum ST2 Levels Be Used as a Marker of Fibrosis in Chronic Hepatitis B Infection?Medicine · 2015Article
- Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.PloS one · 2015Article
- Non-invasive assessment of liver fibrosis in chronic hepatitis B.World journal of gastroenterology · 2014Review
- Clinical approaches to non-alcoholic fatty liver disease.World journal of gastroenterology · 2014Review
- Establishment and validation of a simple noninvasive model to predict significant liver fibrosis in patients with chronic hepatitis B.Hepatology international · 2012Article
- Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.PloS one · 2011Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the efficacy of 6 noninvasive liver fibrosis models and to identify the most valuable model for the prediction of liver fibrosis stage in chronic hepatitis B (CHB) patients.
methodsSeventy-eight CHB patients were consecutively enrolled in this study. Liver biopsy was performed and blood serum was obtained at admission. Histological diagnosis was made according to the METAVIR system. Significant fibrosis was defined as stage score > or = 2, severe fibrosis as stage score > or = 3. The diagnostic accuracy of 6 noninvasive liver fibrosis models, including serum aspartate aminotransferase (AST) to platelet ratio index (APRI), FIB-4, Forn's index, Fibrometer, Hepascore, and Shanghai Liver Fibrosis Group's index (SLFG), was investigated.
resultsThe APRI, FIB-4 and Forn's index under receiver operating characteristic curve (AUROC) for significant fibrosis were 0.71, 0.75 and 0.79, respectively, with a diagnosis accuracy of 67%, 77% and 80%, respectively, and 0.80, 0.87 and 0.86, respectively, under the AUROC for severe fibrosis. The Hepascore, SLFG, and Fibrometer were 0.80, 0.83 and 0.85, respectively under the AUROC for significant fibrosis (P < 0.01). The diagnosis accuracy of Hepascore and SLFG was 86% and 88%, respectively. The Hepascore, SLFG, and Fibrometer were 0.95, 0.93, and 0.94, respectively, under the AUROC for severe fibrosis (P < 0.01).
conclusionThe models containing direct serum markers have a better diagnostic value than those not containing direct serum markers.
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