ArticleAnatomical record (Hoboken, N.J. : 2007)2010
Proteolytic cleavage of versican during limb joint development.
Article in Anatomical record (Hoboken, N.J. : 2007), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Synovial joint cavitation during limb skeletogenesis entails Na/K-ATPase ion pump expression and osmoregulatory activity.Development (Cambridge, England) · 2025Article
- Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development.Matrix biology plus · 2023Article
- Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs.Biology open · 2022Article
- Versican: a novel modulator of hepatic fibrosis.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Versican knockdown reduces interzone area during early stages of chick synovial joint development.Anatomical record (Hoboken, N.J. : 2007) · 2012Article
- Cartilage biology in osteoarthritis--lessons from developmental biology.Nature reviews. Rheumatology · 2011Review
- Versican G1 domain and V3 isoform overexpression results in increased chondrogenesis in the developing chick limb in ovo.Anatomical record (Hoboken, N.J. : 2007) · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Versican is highly expressed in developing joint interzones during limb morphogenesis. This study was undertaken to examine whether proteolytic cleavage of versican occurs that could potentially impact its function during the process of embryonic synovial joint formation. Using an antibody to the DPEAAE neoepitope generated by ADAMTS proteolysis, versican amino terminal cleavage fragments were detected in joint interzones at 12-16 days post coitum (dpc). ADAMTS-1 localization overlapped that of DPEAAE-reactive versican fragments suggesting it as one possible protease activity involved in processing of versican in the interzone. Results show that increased cleavage of versican in the interzone accompanies cavitation and suggests that proteolytic modification of versican may be important during the process of synovial joint maturation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.