ArticleNeurochemical research2010
Alternative complement pathway in schizophrenia.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Charting the proteome landscape in major psychiatric disorders: From biomarkers to biological pathways towards drug discovery.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022Pooled it
- Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies.Schizophrenia research · 2020Pooled it
- Immunological predictors in first-episode psychosis: findings from one-year prospective follow-up study.Acta neuropsychiatrica · 2026Article
- Roles of complement system in psychiatric disorders.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Complement Activation Products in Patients with Chronic Schizophrenia.Journal of clinical medicine · 2023Article
- Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis.Molecular psychiatry · 2022Review
- Neuronal oscillations: early biomarkers of psychiatric disease?Frontiers in behavioral neuroscience · 2022Review
- mRNA Expression of the CUB and Sushi Multiple Domains 1 (ACS omega · 2021Article
- Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.Molecular psychiatry · 2021Article
- Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State.Frontiers in molecular neuroscience · 2021Article
- Inflammatory Pathways in Psychiatric Disorders: The case of Schizophrenia and Depression.Current behavioral neuroscience reports · 2020Article
- The complement system in schizophrenia: where are we now and what's next?Molecular psychiatry · 2020Review
- Complement System in Brain Architecture and Neurodevelopmental Disorders.Frontiers in neuroscience · 2020Review
- Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- C3 Polymorphism Influences Circulating Levels of C3, ASP and Lipids in Schizophrenic Patients.Neurochemical research · 2015Observational
- Innate immunity and neuroinflammation.Mediators of inflammation · 2013Review
- Association of C1QB gene polymorphism with schizophrenia in Armenian population.BMC medical genetics · 2011Article
- Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia.BMC clinical pathology · 2011Article
- Complement: a key system for immune surveillance and homeostasis.Nature immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we evaluated functional activity of the alternative pathway of complement in schizophrenia by measuring the alternative pathway hemolytic activity (AH50) of complement as well as hemolytic activity of the complement C3 component (C3H50) in the blood of patients with schizophrenia and healthy subjects. To assess the influence of neuroleptic treatment on measured parameters, both drug-free and medicated patients were examined. In addition, correlation analysis between AH50 and C3H50 has been performed. The results of the present study clearly demonstrate upregulation of the alternative complement cascade in schizophrenia and activator effect of neuroleptics on complement alternative pathway. Based upon the results obtained we hypothesize that hyperactivation of the alternative complement pathway in schizophrenia is stimulated by apoptotic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.