ArticlePsychopharmacology2010
Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Ontogenic, Immunological, and Behavioral Changes of Crack Cocaine Exposure During the Gestational Period.Molecular neurobiology · 2025Article
- Psychostimulants and social behaviors.Frontiers in pharmacology · 2024Review
- Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring.Psychopharmacology · 2019Article
- Cocaine-associated odor cue re-exposure increases blood oxygenation level dependent signal in memory and reward regions of the maternal rat brain.Drug and alcohol dependence · 2014Article
- Sexual experience increases oxytocin receptor gene expression and protein in the medial preoptic area of the male rat.Psychoneuroendocrinology · 2013Article
- Cocaine sensitization increases kyphosis and modulates neural activity in adult nulliparous rats.Brain sciences · 2012Article
- Effects of cocaine on maternal behavior and neurochemistry.Current neuropharmacology · 2012Article
- A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams.Journal of neuroendocrinology · 2011Review
- Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat.Synapse (New York, N.Y.) · 2011Article
- Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens.Synapse (New York, N.Y.) · 2011Article
- Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.Brain research · 2011Article
- Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems.Frontiers in psychiatry · 2011Article
- Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol.Frontiers in psychiatry · 2011Article
- Brain Reward Pathway Dysfunction in Maternal Depression and Addiction: A Present and Future Transgenerational Risk.Journal of reward deficiency syndromeArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAlthough many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior.
methodsIn the current study, intraperitoneal cocaine or saline was administered to adult female rats for 10 days, treatments were stopped for 4 days, and the females were then mated. Litter size and weight were recorded on days 2 and 16 of lactation, and maternal care, maternal aggression, and light/dark box activity were assessed on days 2, 9, and 16 of lactation.
resultsThe cocaine-treated females exhibited behavioral sensitization on treatment day 10. Mothers previously treated with cocaine retrieved pups more quickly, spent more time caring for the pups (increased pup retrieval, pup grooming, and crouching over the pups by the mother), and were more aggressive towards a male intruder compared to saline-treated control animals on day 2 of lactation. These effects were specific to maternal behavior, as other behaviors were mostly unaffected by prior cocaine treatment. Data from light/dark box tests indicate that cocaine did not affect activity in this test. There were few significant behavioral effects of prior cocaine treatment on lactation days 9 and 16.
conclusionsPrior cocaine use may have lasting effects on offspring care and maternal aggression, specifically during early lactation. The present data support the hypothesis that maternal behavior is increased by prior cocaine sensitization, possibly due to cross-sensitization between cocaine and the natural reward of maternal behavior.
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