ArticleNature genetics2010
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 139 citations in OpenAlex.
- Genetic Regulation of Immune Response in Dogs.Genes · 2025Review
- Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus).Molecular ecology · 2025Article
- Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs.Frontiers in veterinary science · 2025Article
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- Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma.Scientific reports · 2024Article
- Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study.Vaccine · 2024Article
- Genomic Medicine in Canine Periodontal Disease: A Systematic Review.Animals : an open access journal from MDPI · 2023Review
- Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans.Frontiers in oncology · 2023Review
- Review
- The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals.Genes · 2020Review
- Genome wide association study of 40 clinical measurements in eight dog breeds.Scientific reports · 2020Article
- Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.BMC genomics · 2020Article
- What animals can teach us about evolution, the human genome, and human disease.Upsala journal of medical sciences · 2020Review
- Article
- Article
- A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts.European journal of human genetics : EJHG · 2019Article
- The evolutionary dynamics of microRNAs in domestic mammals.Scientific reports · 2018Article
- Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs.PLoS biology · 2018Article
- Applications and efficiencies of the first cat 63K DNA array.Scientific reports · 2018Article
- ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.Scientific reports · 2018Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
The unique canine breed structure makes dogs an excellent model for studying genetic diseases. Within a dog breed, linkage disequilibrium is extensive, enabling genome-wide association (GWA) with only around 15,000 SNPs and fewer individuals than in human studies. Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases) and 57 controls from the Nova Scotia duck tolling retriever breed identified five loci associated with a canine systemic lupus erythematosus (SLE)-related disease complex that includes both antinuclear antibody (ANA)-positive immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). Fine mapping with twice as many dogs validated these loci. Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.