ArticleOncogene2010
Role of DREF in transcriptional regulation of the Drosophila p53 gene.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- ZBED1/DREF: A transcription factor that regulates cell proliferation.Oncology letters · 2020Review
- The Drosophila histone methyltransferase NSD is positively regulated by the DRE/DREF system.Genes & genomics · 2018Article
- Phosphine inhibits transcription of the catalase gene through the DRE/DREF system in Drosophila melanogaster.Scientific reports · 2017Article
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
- The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.Scientific reports · 2014Article
- Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle.Cell cycle (Georgetown, Tex.) · 2013Article
- The warts gene as a novel target of the Drosophila DRE/DREF transcription pathway.American journal of cancer research · 2012Article
- DREF is involved in the steroidogenesis via regulation of shadow gene.American journal of cancer research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor suppressor protein p53 has a critical role in safeguarding the integrity of the genome. Its functions are well understood but factors responsible for the transcriptional regulation of the p53 gene are almost entirely unknown. The DNA replication-related element (DRE)/DNA replication-related element-binding factor (DREF) transcriptional regulatory system is established as a master key to cell proliferation in Drosophila. DREF binds specifically to DRE sequences in the Drosophila p53 (dmp53) gene promoter as shown using anti-DREF antibodies in chromatin immunoprecipitation assays. Furthermore, a rough eye phenotype because of overexpression of DREF in Drosophila eye imaginal disks could be suppressed by half dose reduction of the dmp53 gene. In addition, the level of mRNA of dmp53 was decreased in DREF-knockdown cells and transient expression of the luciferase gene under control of the wild-type dmp53 gene promoter showed strong promoter activity in S2 cells, but this was almost completely abrogated with a DRE-mutated promoter. Requirement of DREs for dmp53 promoter activity was further confirmed by anti-beta-galactosidase antibody-staining of various tissues from transgenic flies carrying dmp53 promoter-lacZ fusion genes. These results indicate that DREF is necessary for dmp53 gene promoter activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.