ArticleThe Journal of clinical investigation2010
The role of genetic diversity in cancer.
Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Forward-reverse mutation cycles in cancer cell lines under chemical treatments.Human genomics · 2024Article
- The Clinical Significance of Genetic Variation in Ovarian Cancer.International journal of molecular sciences · 2023Article
- Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models.Computational and structural biotechnology journal · 2020Article
- Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells.The Prostate · 2018Article
- Rethinking Causation in Cancer with Evolutionary Developmental Biology.Biological theory · 2018Article
- Evolutionary scalpels for dissecting tumor ecosystems.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks.Cold Spring Harbor perspectives in medicine · 2017Review
- Domesticating Cancer: An Evolutionary Strategy in the War on Cancer.Frontiers in oncology · 2017Article
- Research Needs for Understanding the Biology of Overdiagnosis in Cancer Screening.Journal of cellular physiology · 2016Review
- The challenge of targeting metastasis.Cancer metastasis reviews · 2015Review
- Clinicopathological significance of cancer stem-like cell markers in high-grade neuroendocrine carcinoma of the lung.Journal of cancer research and clinical oncology · 2015Article
- Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Heterogeneity of excision repair cross-complementation group 1 gene expression in non-small-cell lung cancer patients.Molecular and clinical oncology · 2015Article
- Cancer Bioinformatic Methods to Infer Meaningful Data From Small-Size Cohorts.Cancer informatics · 2015Review
- Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Cell division · 2015Article
- Clinical significance of the stem cell gene Oct-4 in cervical cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Review
- EXPANDS: expanding ploidy and allele frequency on nested subpopulations.Bioinformatics (Oxford, England) · 2014Article
- Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death.Cancer discovery · 2013Article
- Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance.Interface focus · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The role of genetic heterogeneity within neoplasms is increasingly recognized as important for understanding the dynamics of cancer progression, cancer stem cells, and therapeutic resistance, and there is interest in intratumoral heterogeneity measurements as potential biomarkers for risk stratification. In this issue of the JCI, Park et al. characterize this genetic diversity in carcinoma in situ and in invasive regions from 3 types of human breast cancers and lay the groundwork for translation of these measures to the clinic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.