ArticleHypertension (Dallas, Tex. : 1979)2010
Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats.
Article in Hypertension (Dallas, Tex. : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 103 citations in OpenAlex.
- A redox sensor in protein kinase A regulatory subunit Iα regulates vasodilation and protects against hypertension.Redox biology · 2026Article
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Left Out in the Cold? The Sympathetic Signature of Cold-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Influence of sex and sedentary conditions on sympathetic burst characteristics in prepubertal, postpubertal, and young adult rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Sympathoexcitatory responses to renal chemosensitive stimuli are exaggerated at nighttime in rats.American journal of physiology. Heart and circulatory physiology · 2022Article
- Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development.Frontiers in physiology · 2021Review
- Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity.American journal of physiology. Heart and circulatory physiology · 2021Article
- Direct comparison of cervical and high thoracic spinal cord injury reveals distinct autonomic and cardiovascular consequences.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats.International journal of ophthalmology · 2019Article
- Systemic angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep.Bioscience reports · 2018Article
- Burst patterning of hypothalamic paraventricular nucleus-driven sympathetic nerve activity in ANG II-salt hypertension.American journal of physiology. Heart and circulatory physiology · 2018Article
- Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.Journal of visualized experiments : JoVE · 2018Article
- Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.Physiological reports · 2018Article
- Obstructive sleep apnea is associated with altered midbrain chemical concentrations.Neuroscience · 2017Article
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- What can we learn about neural control of the cardiovascular system by studying rhythms in sympathetic nerve activity?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Review
- Neural Control of Non-vasomotor Organs in Hypertension.Current hypertension reports · 2016Review
- Major Autonomic Neuroregulatory Pathways Underlying Short- and Long-Term Control of Cardiovascular Function.Current hypertension reports · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Angiotensin II (AngII)-induced hypertension in experimental animals has been proposed to be attributed in part to activation of the sympathetic nervous system. This sympathetic activation appears to be accentuated in animals consuming a high-salt diet (AngII-salt hypertension). However, accurate quantification of sympathetic activity is difficult, and controversy remains. It is particularly important to ask which are the critical vascular beds targeted by increased sympathetic nerve activity (SNA) in AngII-salt hypertension. To address this issue, mean arterial pressure and renal SNA or lumbar SNA were continuously recorded during a 5-day control period, 11 days of AngII (150 ng/kg per minute, SC), and a 5-day recovery period in conscious rats on a high-salt (2% NaCl) diet. Although mean arterial pressure reached a new steady-state level of 30 to 35 mm Hg above control levels by the end of the AngII period, renal SNA decreased by 40% during the first 7 days of AngII and then returned toward control levels by day 10 of AngII. In contrast, lumbar SNA remained at control levels throughout the AngII period. In another experiment we measured hindlimb norepinephrine spillover in conscious rats on normal (0.4%) or high- (2.0%) salt diets before and during 14 days of AngII administration. AngII had no significant affect on hindlimb norepinephrine spillover in either group. We conclude that chronic AngII modulates renal and lumbar SNAs differentially in rats consuming a high-salt diet and that AngII-salt hypertension in the rat is not caused by increased SNA to the renal or hindlimb vascular beds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.