ArticleJournal of immunology (Baltimore, Md. : 1950)2010
CD72 negatively regulates KIT-mediated responses in human mast cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.Biomolecules · 2023Article
- Review
- Neonatal Fc receptor induces intravenous immunoglobulin growth suppression in Langerhans cell histiocytosis.Pathology international · 2021Article
- Strategies for Mast Cell Inhibition in Food Allergy.The Yale journal of biology and medicine · 2020Review
- Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis.International journal of molecular sciences · 2020Review
- Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration.Frontiers in immunology · 2019Article
- The role of semaphorins in immune responses and autoimmune rheumatic diseases.Nature reviews. Rheumatology · 2018Review
- CD100 Effects in Macrophages and Its Roles in Atherosclerosis.Frontiers in cardiovascular medicine · 2018Review
- Killer cell immunoglobulin-like receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis.Oncotarget · 2017Article
- CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.Cancer medicine · 2017Article
- CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1.Scientific reports · 2013Article
- Novel identified receptors on mast cells.Frontiers in immunology · 2012Article
- Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Biology and function of neuroimmune semaphorins 4A and 4D.Immunologic research · 2011Review
- Regulation of mast cell responses in health and disease.Critical reviews in immunology · 2011Review
- Mast cells.Current gastroenterology reports · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
KIT activation, through binding of its ligand, stem cell factor, is crucial for normal mast cell growth, differentiation, and survival. Furthermore, KIT may also contribute to mast cell homing and cytokine generation. Activating mutations in KIT lead to the dysregulated mast cell growth associated with the myeloproliferative disorder, mastocytosis. We investigated the potential of downregulating such responses through mast cell inhibitory receptor activation. In this study, we report that the B cell-associated ITIM-containing inhibitory receptor, CD72, is expressed in human mast cells. Ligation of CD72 with the agonistic Ab, BU40, or with recombinant human CD100 (rCD100), its natural ligand, induced the phosphorylation of CD72 with a resulting increase in its association with the tyrosine phosphatase SH2 domain-containing phosphatase-1. This, in turn, resulted in an inhibition of KIT-induced phosphorylation of Src family kinases and extracellular-regulated kinases (ERK1/2). As a consequence of these effects, KIT-mediated mast cell proliferation, chemotaxis, and chemokine production were significantly reduced by BU40 and rCD100. Furthermore, BU40 and rCD100 also downregulated the growth of the HMC1.2 human mast cell line. Thus, targeting CD72 may provide a novel approach to the suppression of mast cell disease such as mastocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.