ArticleMolecular and cellular biology2010
Regulation of RB transcription in vivo by RB family members.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Non-canonical pathway for Rb inactivation and external signaling coordinate cell-cycle entry without CDK4/6 activity.Nature communications · 2023Article
- Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer.Cold Spring Harbor perspectives in medicine · 2023Article
- Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro.International journal of molecular sciences · 2022Article
- Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S.Oncogenesis · 2020Article
- Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.The Journal of experimental medicine · 2019Article
- HOTAIR, a long noncoding RNA, is a marker of abnormal cell cycle regulation in lung cancer.Cancer science · 2018Article
- E47 Governs the MYC-CDKN1B/p27Cellular and molecular gastroenterology and hepatology · 2018Article
- Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis.Oncotarget · 2017Article
- CDK4/6 Inhibitors in Cancer Therapy: A Novel Treatement Strategy for Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2017Review
- Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.Cell stem cell · 2015Article
- The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.Molecular cancer · 2014Article
- Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.Neuro-oncology · 2014Article
- Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells.Oncology letters · 2014Article
- Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.The Journal of experimental medicine · 2013Article
- Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif.Nature communications · 2013Article
- Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.G3 (Bethesda, Md.) · 2012Article
- Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.BMC cancer · 2012Article
- Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.The Journal of experimental medicine · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase activity. While variations in RB levels may also provide an important means of controlling RB function in both normal and cancer cells, little is known about the mechanisms regulating RB transcription. Here we show that members of the RB and E2F families bind directly to the RB promoter. To investigate how the RB/E2F pathway may regulate Rb transcription, we generated reporter mice carrying an eGFP transgene inserted into a bacterial artificial chromosome containing most of the Rb gene. Expression of eGFP largely parallels that of Rb in transgenic embryos and adult mice. Using these reporter mice and mutant alleles for Rb, p107, and p130, we found that RB family members modulate Rb transcription in specific cell populations in vivo and in culture. Interestingly, while Rb is a target of the RB/E2F pathway in mouse and human cells, Rb expression does not strictly correlate with the cell cycle status of these cells. These experiments identify novel regulatory feedback mechanisms within the RB pathway in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.