Evidence map›Paper›PMID 20100734›Full record

Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2010

Effect of intra-dialytic, low-intensity strength training on functional capacity in adult haemodialysis patients: a randomized pilot trial.

Joline L T Chen, Susan Godfrey, Tan Tan Ng, Ranjani Moorthi, Orfeas Liangos, Robin Ruthazer, Bertrand L Jaber, Andrew S Levey, Carmen Castaneda-Sceppa

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 12 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 12 syntheses or guidelines pooled it, 202 citations in OpenAlex.

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  6. Effects of intradialytic exercise on health-related quality of life in patients undergoing maintenance haemodialysis: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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  7. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
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  12. Exercise training for adults with chronic kidney disease.The Cochrane database of systematic reviews · 2011
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Joline L T ChenThe Renal Section, Boston University School of Medicine, Boston, MA, USA.
Susan Godfrey
Tan Tan Ng
Ranjani Moorthi
Orfeas Liangos
Robin Ruthazer
Bertrand L Jaber
Andrew S Levey
Carmen Castaneda-Sceppa
Tufts Medical Center · USSt. Elizabeth's Medical Center · USBoston University · USJean Mayer Human Nutrition Research Center on Aging · USTufts University · USUniversity of Milan · IT

Funding

ZIDOVUDINE &LAMIVUDINE ALONE OR IN COMBINATION ON BODY COMPOSITIONM01RR000054 · NCRR · TUFTS MEDICAL CENTER · PI RAO, MADHUMATHI · 1985 to 2005
$12.2M
Epidemiology, Clinical Trials and Outcomes Research In NephrologyT32DK007777 · NIDDK · TUFTS MEDICAL CENTER · PI SARNAK, MARK J · 1999 to 2020
$4.1M
Resistance Training during Maintenance DialysisR03DK064825 · NIDDK · TUFTS UNIVERSITY BOSTON · PI SCEPPA, CARMEN CASTANEDA · 2003 to 2004
$286k
NCRR NIH HHS M01 RR000054NIDDK NIH HHS R03 DK064825NIDDK NIH HHS T32 DK0 07777NIDDK NIH HHS T32 DK007777
6 · The paper itself

Abstract

backgroundKidney failure is associated with muscle wasting and physical impairment. Moderate- to high-intensity strength training improves physical performance, nutritional status and quality of life in people with chronic kidney disease and in dialysis patients. However, the effect of low-intensity strength training has not been well documented, thus representing the objective of this pilot study.

methodsFifty participants (mean +/- SD, age 69 +/- 13 years) receiving long-term haemodialysis (3.7 +/- 4.2 years) were randomized to intra-dialytic low-intensity strength training or stretching (attention-control) exercises twice weekly for a total of 48 exercise sessions. The primary study outcome was physical performance assessed by the Short Physical Performance Battery score (SPPB) after 36 sessions, if available, or carried forward from 24 sessions. Secondary outcomes included lower body strength, body composition and quality of life. Measurements were obtained at baseline and at completion of 24 (mid), 36 (post) and 48 (final) exercise sessions.

resultsBaseline median (IQR) SPPB score was 6.0 (5.0), with 57% of the participants having SPPB scores below 7. Exercise adherence was 89 +/- 15%. The primary outcome could be computed in 44 participants. SPPB improved in the strength training group compared to the attention-control group [21.1% (43.1%) vs. 0.2% (38.4%), respectively, P = 0.03]. Similarly, strength training participants exhibited significant improvements from baseline compared to the control group in knee extensor strength, leisure-time physical activity and self-reported physical function and activities of daily living (ADL) disability; all P < 0.02. Adverse events were common but not related to study participation.

conclusionsIntra-dialytic, low-intensity progressive strength training was safe and effective among maintenance dialysis patients. Further studies are needed to establish the generalizability of this strength training program in dialysis patients.

Indexed as

Renal DialysisAgedAged, 80 and overBody CompositionFemaleHumansKidney Failure, ChronicMaleMiddle AgedMuscle StrengthQuality of LifeResistance TrainingTreatment Outcome

Identifiers

PMID20100734
PMCPMC2902890
OpenAlexW2142385157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.