ArticleBMC genomics2010
Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Genomic sequence and structural variations accumulating between laboratory lineages of wild typebioRxiv : the preprint server for biology · 2026Article
- CGC1, a new reference genome forGenome research · 2025Article
- Transposable elements and heterochromatic regions are enriched for structural variation and sequence divergence in the genome of wild-type Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Comprehensive detection of structural variation and transposable element differences between wild type laboratory lineages ofbioRxiv : the preprint server for biology · 2023Article
- Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line.G3 (Bethesda, Md.) · 2023Article
- Genome Size Changes by Duplication, Divergence, and Insertion in Caenorhabditis Worms.Molecular biology and evolution · 2023Article
- Bergerac strains of Caenorhabditis elegans revisited: expansion of Tc1 elements imposes a significant genomic and fitness cost.G3 (Bethesda, Md.) · 2022Article
- IntraspecificNAR genomics and bioinformatics · 2022Article
- The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels.Nature cell biology · 2021Article
- Molecular Characterization and Functional Analysis of theFrontiers in physiology · 2021Article
- A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans.PLoS genetics · 2020Article
- Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation inGenome research · 2019Article
- Mutational and transcriptional landscape of spontaneous gene duplications and deletions inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Non-Mendelian assortment of homologous autosomes of different sizes in males is the ancestral state in the Caenorhabditis lineage.Scientific reports · 2017Article
- Effect of mutation mechanisms on variant composition and distribution in Caenorhabditis elegans.PLoS computational biology · 2017Article
- Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans.BMC genomics · 2015Article
- When natural selection gives gene function the cold shoulder.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- High evolutionary turnover of satellite families in Caenorhabditis.BMC evolutionary biology · 2015Article
- Early evolutionary history and genomic features of gene duplicates in the human genome.BMC genomics · 2015Article
- No Evidence that MicroRNAs Coevolve with Genes Located in Copy Number Regions.Molecular biology and evolution · 2015Article
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5 authors.
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Abstract
backgroundCopy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain.
resultsWe have used array comparative genomic hybridization (aCGH) to detect copy number variation in the genomes of 12 natural isolates of Caenorhabditis elegans. Deletions relative to the canonical N2 strain are more common in these isolates than duplications, and indels are enriched in multigene families on the autosome arms. Among the strains in our study, the Hawaiian and Madeiran strains (CB4856 and JU258) carry the largest number of deletions, followed by the Vancouver strain (KR314). Overall we detected 510 different deletions affecting 1136 genes, or over 5% of the genes in the canonical N2 genome. The indels we identified had a median length of 2.7 kb. Since many deletions are found in multiple isolates, deletion loci were used as markers to derive an unrooted tree to estimate genetic relatedness among the strains.
conclusionCopy number variation is extensive in C. elegans, affecting over 5% of the genes in the genome. The deletions we have detected in natural isolates of C. elegans contribute significantly to the number of deletion alleles available to researchers. The relationships between strains are complex and different regions of the genome possess different genealogies due to recombination throughout the natural history of the species, which may not be apparent in studies utilizing smaller numbers of genetic markers.
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