ArticleBMC musculoskeletal disorders2010
Increased expression of collagens, transforming growth factor-beta1, and -beta3 in gluteal muscle contracture.
Article in BMC musculoskeletal disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Gluteal Fibrosis and Its Surgical Treatment.The Journal of bone and joint surgery. American volume · 2019Pooled it
- Effects of Neuromuscular Electrical Stimulation and Therapeutic Ultrasound on Quadriceps Contracture of Immobilized Rats.Veterinary sciences · 2024Article
- The pattern of collagen production may contribute to the gluteal muscle contracture pathogenic process.Journal of orthopaedic surgery and research · 2023Article
- miR-491-5p inhibits Emilin 1 to promote fibroblasts proliferation and fibrosis in gluteal muscle contracture via TGF-Beta1/Smad2 pathway.Physiological research · 2022Article
- Spinal-pelvic sagittal parameters in patients with gluteal muscle contracture: an imaging study.PeerJ · 2022Article
- miR-29a is a potential protective factor for fibrogenesis in gluteal muscle contracture.Physiological research · 2020Article
- Histology and molecular pathology of iliotibial tract contracture in patients with gluteal muscle contracture.Bioscience reports · 2019Article
- Shear-wave elastography assessment of gluteal muscle contracture: Three case reports.Medicine · 2018Article
- Comparison of the clinical effects of arthroscopic surgery vs. open surgery for grade II gluteal muscle contracture in adults.Experimental and therapeutic medicine · 2018Article
- The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis.Frontiers in pharmacology · 2018Review
- Positive Association betweenAnalytical cellular pathology (Amsterdam) · 2018Article
- Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis.Frontiers in pharmacology · 2017Review
- Gluteal muscle fibrosis with abduction contracture of the hip.International orthopaedics · 2016Article
- Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture.Connective tissue research · 2015Article
- Congenital gluteus maximus contracture syndrome--a case report with review of imaging findings.Journal of radiology case reports · 2014Article
- Transforming growth factor-beta (TGF- β) signaling in paravertebral muscles in juvenile and adolescent idiopathic scoliosis.BioMed research international · 2014Article
- Postulating a role for connective tissue elements in inferior oblique muscle overaction (an American Ophthalmological Society thesis).Transactions of the American Ophthalmological Society · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGluteal muscle contracture (GMC) is a multi-factor human chronic fibrotic disease of the gluteal muscle. Fibrotic tissue is characterized by excessive accumulation of collagen in the muscle's extracellular matrix. Transforming growth factor (TGF)-beta1 and -beta2 are thought to play an important role in fibrogenesis, while TGF-beta3 is believed to have an anti-fibrotic function. We hypothesize that the expression of collagen and TGF-betas would be up-regulated in GMC patients.
methodsThe expression of collagen type I, type III and TGF-betas were studied in 23 fibrotic samples and 23 normal/control samples in GMC patients using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and western bolt analysis.
resultsCompared to the unaffected adjacent muscle, increased expression of TGF-beta1 and -beta3 was associated with deposition of collagen type I and type III in the fibrotic muscle of the GMC patients at the mRNA level. Strong up-regulation of these proteins in fibrotic muscle was confirmed by immunohistochemical staining and western blot analysis. TGF-beta2 was not up-regulated in relation to GMC.
conclusionThis study confirmed our hypothesis that collagen types I, III, TGF-beta1 and TGF-beta3 were up-regulated in biopsy specimens obtained from patients with GMC. Complex interaction of TGF-beta1 with profibrotic function and TGF-beta3 with antifibrotic function may increase synthesis of collagens and thereby significantly contribute to the process of gluteal muscle scarring in patients with GMC.
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Registered trials
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