ArticleHeadache2010
Migraine, migraine features, and cardiovascular disease.
Article in Headache, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Comorbidities of primary headache disorders: a literature review with meta-analysis.The journal of headache and pain · 2021Pooled it
- Guideline
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Value of Combination Therapy With Antiepileptic Drugs (AEDs) for Migraine to Prevent Ischemic Stroke in Young Women.Cureus · 2022Article
- Factors Associated With, and Mitigation Strategies for, Health Care Disparities Faced by Patients With Headache Disorders.Neurology · 2021Review
- A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection.Headache · 2021Review
- Cerebrovascular disease in women.Therapeutic advances in neurological disorders · 2021Review
- Coronary artery calcification score in migraine patients.Scientific reports · 2019Article
- Temporal Integration of Motion Streaks in Migraine.Vision (Basel, Switzerland) · 2018Article
- Juvenile Stroke.Deutsches Arzteblatt international · 2017Review
- Embolic Strokes of Unknown Source and Cryptogenic Stroke: Implications in Clinical Practice.Frontiers in neurology · 2016Review
- Assessment of pyridoxine and folate intake in migraine patients.Advanced biomedical research · 2016Article
- Positive effects of the progestin desogestrel 75 μg on migraine frequency and use of acute medication are sustained over a treatment period of 180 days.The journal of headache and pain · 2015Article
- Review
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- Gastric stasis in migraineurs: etiology, characteristics, and clinical and therapeutic implications.Cephalalgia : an international journal of headache · 2013Review
- The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis.Experimental and therapeutic medicine · 2012Article
- High Density Lipoprotein and it's Dysfunction.The open biochemistry journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundMany studies support an association between migraine and cardiovascular disease (CVD). This association appears particularly in migraine with aura and is also modified by additional factors.
objectiveWe sought to investigate whether the association between migraine and CVD in addition to aura status is affected by certain migraine features.
methodsCohort study among 27,840 women, participating in the Women's Health Study. We had detailed self-reported information on migraine and migraine features among women with active migraine (migraine during the year prior to baseline). Incident CVD events were confirmed after medical record review. We used Cox proportional hazards models to evaluate the association between migraine and incident CVD. The results have been presented in part before. We ran additional analyses according to migraine features.
resultsAt baseline, 5125 (18.4%) women reported history of migraine; 39.7% of the 3610 women with active migraine indicated aura. During a mean of 11.9 years of follow-up, 708 CVD events occurred. Migraine with aura doubled the risk for CVD, ischemic stroke, and myocardial infarction. With regard to ischemic stroke, this association seemed stronger in the absence than in the presence of migraine features. This was most pronounced in the absence (hazard ratio = 3.27; 95% CI = 1.93-5.51; P < .0001) than in the presence of nausea/vomiting (hazard ratio = 0.91; 95% CI = 0.43-1.93; P = .80). In contrast, the association with myocardial infarction did not reveal a certain pattern.
conclusionsThese data suggest that the association between migraine with aura and ischemic stroke may differ by absence or presence of migraine features.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.