ArticleBioscience reports2010
Overexpression of xCT induces up-regulation of 14-3-3beta in Kaposi's sarcoma.
Article in Bioscience reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Associative study of human herpesvirus 8 and Kaposi's sarcoma: Mapping viral oncogenic properties and the clinical scenario in oncological patients.Immunologic research · 2025Review
- A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers.Cancers · 2022Article
- Nrf2-Mediated System xMolecular neurobiology · 2019Article
- 14-3-3β exerts glioma-promoting effects and is associated with malignant progression and poor prognosis in patients with glioma.Experimental and therapeutic medicine · 2018Article
- Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells.Oncotarget · 2017Article
- Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma.Cancers · 2015Review
- xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases.Frontiers in microbiology · 2015Article
- The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Antioxidants & redox signaling · 2013Review
- Neurotransmitter signaling in the pathophysiology of microglia.Frontiers in cellular neuroscience · 2013Article
- Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.Journal of virology · 2013Article
- Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen and angiogenin interact with common host proteins, including annexin A2, which is essential for survival of latently infected cells.Journal of virology · 2012Article
- System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.British journal of pharmacology · 2012Article
- Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma.The American journal of pathology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KSHV (Kaposi's sarcoma-associated herpesvirus), or HHV-8 (human herpesvirus 8), is associated with the pathogenesis of KS, the most common AIDS-related malignancy. xCT (functional subunit of the cystine/glutamate transporter xc- system) is known as the HHV-8 fusion-entry receptor as well as an oncogenic protein. How the xCT triggers the signal transduction of HHV-8 infection and the cell proliferation remains incomplete. We found that xCT was overexpressed in KS tissues and HHV-8-positive BCBL-1 cells. When xCT cDNA plasmids were transfected into the HHV-8-negative BJAB cells, the expression of 14-3-3beta and cell growth rate were increased. In contrast, the expression of 14-3-3beta and the cell growth rate of HHV-8-positive BCBL-1 cells were suppressed by either xCT siRNA (short interfering RNA) or an xCT inhibitor, sulfsalazine. These results suggest that 14-3-3beta is a downstream effector of xCT in KS to mediate the cell proliferation.
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