Evidence map›Paper›PMID 20099843›Full record

ArticleBioconjugate chemistry2010

Synthesis and bioconjugation of 2 and 3 nm-diameter gold nanoparticles.

Christopher J Ackerson, Pablo D Jadzinsky, Jonathan Z Sexton, David A Bushnell, Roger D Kornberg

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 119 citations in OpenAlex.

  1. Cloneable contrast across all biological length scales.Journal of structural biology · 2026
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  10. Unraveling the long-pursued AuScience advances · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher J AckersonDepartment of Structural Biology, Stanford School of Medicine, 299 Campus Drive West, Stanford, California 94305, USA.
Pablo D Jadzinsky
Jonathan Z Sexton
David A Bushnell
Roger D Kornberg
Stanford Medicine · US

Funding

Structure of the Eukaryote Transcription ApparatusR01AI021144 · NIAID · STANFORD UNIVERSITY · PI KORNBERG, ROGER D · 1985 to 2018
$10.3M
NIAID NIH HHS AI21144NIAID NIH HHS R01 AI021144
6 · The paper itself

Abstract

By adjustment of solvent conditions for synthesis, virtually monodisperse 4-mercaptobenzoic acid (p-MBA) monolayer-protected gold nanoparticles, 2 and 3 nm in diameter, were obtained. Large single crystals of the 2 nm particles could be grown from the reaction mixture. Uniformity was also demonstrated by the formation of two-dimensional arrays and by quantitative high-angle annular dark-field scanning transmission electron microscopy. The 2 and 3 nm particles were spontaneously reactive for conjugation with proteins and DNA, and further reaction could be prevented by repassivation with glutathione. Conjugates with antibody Fc fragment could be used to identify TAP-tagged proteins of interest in electron micrographs, through the binding of a pair of particles to the pair of protein A domains in the TAP tag.

Indexed as

Particle SizeBenzoatesCysteineDNAGoldMetal NanoparticlesMicroscopy, ElectronMutationProteinsSulfhydryl CompoundsThionucleotides4-mercaptobenzoateBenzoatesCysteineDNAGoldProteinsSulfhydryl CompoundsThionucleotides

Identifiers

PMID20099843
PMCPMC3113727
OpenAlexW1979013297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.