ReviewTheScientificWorldJournal2010
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.
Review in TheScientificWorldJournal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human.Aging · 2016Pooled it
- The Metabolic Reprogramming Mechanism by Pueraria Lobata Fermentation Enhances Saccharomyces cerevisiae Reducing-Sugar-Releasing Activity and Polypeptide Synthesis.Current microbiology · 2026Article
- Fasting, Physical Activity, and Art Therapy Improve Metabolic Syndrome and Inflammasomes: An Italian Residential Experience.Journal of lifestyle medicine · 2025Article
- Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age.Pituitary · 2021Review
- Brain insulin signaling and cerebrovascular disease in human postmortem brain.Acta neuropathologica communications · 2021Article
- The Versatility of Sirtuin-1 in Endocrinology and Immunology.Frontiers in cell and developmental biology · 2020Review
- Longevity: Lesson from Model Organisms.Genes · 2019Review
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Starvation, Stress Resistance, and Cancer.Trends in endocrinology and metabolism: TEM · 2018Review
- The Essential Role of SIRT1 in Hypothalamic-Pituitary Axis.Frontiers in endocrinology · 2018Review
- The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Yeast longevity promoted by reversing aging-associated decline in heavy isotope content.NPJ aging and mechanisms of disease · 2016Article
- Chronic kidney disease and premature ageing.Nature reviews. Nephrology · 2014Review
- Yeast sirtuins and the regulation of aging.FEMS yeast research · 2014Review
- Genetics and epigenetics of aging and longevity.Cell cycle (Georgetown, Tex.) · 2014Review
- The decay of stem cell nourishment at the niche.Rejuvenation research · 2013Review
- Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.Aging cell · 2013Article
- Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons.Brain, behavior, and immunity · 2012Article
- Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.Sub-cellular biochemistry · 2012Review
- Bitter taste receptor polymorphisms and human aging.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. Over the past 10 years, several studies confirmed this conserved molecular strategy of longevity regulation, and many more have been added to the complex mosaic that links stress resistance and aging. In this review, we will analyze the similarities that have emerged over the last decade between longevity regulatory pathways in organisms ranging from yeast, nematodes, and fruit flies to mice. We will focus on the role of yeast signal transduction proteins Ras, Tor, Sch9, Sir2, their homologs in higher organisms, and their association to oxidative stress and protective systems. We will discuss how the "molecular strategy" responsible for life span extension in response to dietary and genetic manipulations appears to be remarkably conserved in various organisms and cells, including neuronal cells in different organisms. Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.