ArticlePloS one2010
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 190 citations in OpenAlex.
- Genomic Insights into a New Burkholderia cenocepacia Sequence Type Linked to Cepacia Syndrome in Cystic Fibrosis.Current microbiology · 2026Article
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- Genome-wide mapping of cyclic AMP receptor protein binding in EnteroaggregativebioRxiv : the preprint server for biology · 2025Article
- Genome-wide mapping of cAMP receptor protein binding in enteroaggregativeMicrobiology (Reading, England) · 2025Article
- Genomic insight into the high-risk hypervirulent multidrug resistant enteroaggregative-hemorrhagicGene reports · 2025Article
- Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregativeMicrobiology (Reading, England) · 2025Article
- Thermothelomyces thermophilus exo- and endo-glucanases as tools for pathogenic E. coli biofilm degradation.Scientific reports · 2024Article
- Lactic acid bacteria isolated from women' breast milk and infants' faeces have appreciable immunogenic and probiotic potentials against diarrheagenic E. coli strains.BMC microbiology · 2024Article
- Genomic Dissection of an EnteroaggregativeInternational journal of molecular sciences · 2024Article
- Infection of mice by the enteroaggregative E. coli strain 042 and two mutant derivatives overexpressing virulence factors: impact on disease markers, gut microbiota and concentration of SCFAs in feces.Scientific reports · 2024Article
- Genetic distribution, characterization, and function ofiScience · 2024Review
- The emergence of the tetrathionate reductase operon in the Escherichia coli/Shigella pan-genome.MicrobiologyOpen · 2022Article
- Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli.PLoS neglected tropical diseases · 2022Article
- Differential Expression of Two Copies of theMicrobiology spectrum · 2022Article
- The microbial ecology of Escherichia coli in the vertebrate gut.FEMS microbiology reviews · 2022Review
- Characterization of UropathogenicMicroorganisms · 2022Article
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- The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenicVirulence · 2021Article
- Modulation of AggR levels reveals features of virulence regulation in enteroaggregative E. coli.Communications biology · 2021Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundEscherichia coli can experience a multifaceted life, in some cases acting as a commensal while in other cases causing intestinal and/or extraintestinal disease. Several studies suggest enteroaggregative E. coli are the predominant cause of E. coli-mediated diarrhea in the developed world and are second only to Campylobacter sp. as a cause of bacterial-mediated diarrhea. Furthermore, enteroaggregative E. coli are a predominant cause of persistent diarrhea in the developing world where infection has been associated with malnourishment and growth retardation.
methodsIn this study we determined the complete genomic sequence of E. coli 042, the prototypical member of the enteroaggregative E. coli, which has been shown to cause disease in volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains revealing previously uncharacterised virulence factors including a variety of secreted proteins and a capsular polysaccharide biosynthetic locus. In addition, by using Biolog Phenotype Microarrays we have provided a full metabolic profiling of E. coli 042 and the non-pathogenic lab strain E. coli K-12. We have highlighted the genetic basis for many of the metabolic differences between E. coli 042 and E. coli K-12.
conclusionThis study provides a genetic context for the vast amount of experimental and epidemiological data published thus far and provides a template for future diagnostic and intervention strategies.
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