ArticlePloS one2010
ChIP-chip designs to interrogate the genome of Xenopus embryos for transcription factor binding and epigenetic regulation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development.Development (Cambridge, England) · 2014Article
- Article
- The epigenome in early vertebrate development.Genesis (New York, N.Y. : 2000) · 2012Review
- Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays.PloS one · 2010Article
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6 authors at 3 institutions in 2 countries.
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Abstract
backgroundChromatin immunoprecipitation combined with genome tile path microarrays or deep sequencing can be used to study genome-wide epigenetic profiles and the transcription factor binding repertoire. Although well studied in a variety of cell lines, these genome-wide profiles have so far been little explored in vertebrate embryos. PRINCIPAL
findingsHere we report on two genome tile path ChIP-chip designs for interrogating the Xenopus tropicalis genome. In particular, a whole-genome microarray design was used to identify active promoters by close proximity to histone H3 lysine 4 trimethylation. A second microarray design features these experimentally derived promoter regions in addition to currently annotated 5' ends of genes. These regions truly represent promoters as shown by binding of TBP, a key transcription initiation factor.
conclusionsA whole-genome and a promoter tile path microarray design was developed. Both designs can be used to study epigenetic phenomena and transcription factor binding in developing Xenopus embryos.
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