Evidence map›Paper›PMID 20098636›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2009

Nanoparticle PEBBLE sensors in live cells and in vivo.

Yong-Eun Koo Lee, Ron Smith, Raoul Kopelman

Abstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 188 citations in OpenAlex.

  1. Review
  2. Article
  3. Nanoparticles for Interrogation of Cell Signaling.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. How hot are single cells?The Journal of general physiology · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yong-Eun Koo LeeDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA. yeleekoo@umich.edu
Ron Smith
Raoul Kopelman
University of Michigan–Ann Arbor · US

Funding

Nanoparticle Enabled Intraoperative Imaging and TherapyR01EB007977 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOPELMAN, RAOUL · 2007 to 2009
$2.8M
Nanobiophotonics Enabled Tumor Surgery and Intraoperative PDTR33CA125297 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOPELMAN, RAOUL · 2008 to 2010
$1.5M
Nanobiophotonics Enabled Tumor Surgery and Intraoperative PDTR21CA125297 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOPELMAN, RAOUL · 2007 to 2007
$228k
Diffused Optical Tomography using Oxygen-sensitive Luminescent Contrast Agent forR41CA130518 · NCI · RADIATION MONITORING DEVICES, INC. · PI GURJAR, RAJAN · 2007 to 2007
$210k
NCI NIH HHS 1R41 CA 130518-01A1NCI NIH HHS R21 CA125297NCI NIH HHS R21/R33 CA125297NCI NIH HHS R33 CA125297NCI NIH HHS R41 CA130518NIBIB NIH HHS 1R01-EB-007977-01NIBIB NIH HHS R01 EB007977
6 · The paper itself

Abstract

Nanoparticle sensors have been developed for real-time imaging and dynamic monitoring, both in live cells and in vivo, of molecular and ionic components, constructs, forces, and dynamics observed during biological, chemical, and physical processes. With their biocompatible small size and inert matrix, nanoparticle sensors have been successfully applied to noninvasive real-time measurements of analytes and fields in cells and in rodents, with spatial, temporal, physical, and chemical resolution. This review describes the diverse designs of nanoparticle sensors for ions and small molecules, physical fields, and biological features, as well as the characterization, properties, and applications of these nanosensors to in vitro and in vivo measurements. Their floating as well as localization abilities in biological media are captured by the acronym PEBBLE: photonic explorer for bioanalysis with biologically localized embedding.

Indexed as

AnimalsBiosensing TechniquesHumansNanoparticlesNanotechnologychemiluminescencefluorescenceionLSPRmoleculeMRINano-sensorROSSERS

Identifiers

PMID20098636
PMCPMC2809932
OpenAlexW2160572948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.