ReviewMarine drugs2009
Towards commercial production of sponge medicines.
Review in Marine drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Article
- Review
- Isolation of anticancer bioactive secondary metabolites from the sponge-derived endophytic fungiFrontiers in microbiology · 2023Article
- A Soft Spot for Chemistry-Current Taxonomic and Evolutionary Implications of Sponge Secondary Metabolite Distribution.Marine drugs · 2021Review
- Application of in situ cultivation in marine microbial resource mining.Marine life science & technology · 2021Review
- Triggering Growth via Growth Initiation Factors in Nature: A Putative Mechanism forFrontiers in microbiology · 2021Article
- Sustainable Low-Volume Analysis of Environmental Samples by Semi-Automated Prioritization of Extracts for Natural Product Research (SeaPEPR).Marine drugs · 2020Article
- Genetic algorithm as an optimization tool for the development of sponge cell culture media.In vitro cellular & developmental biology. Animal · 2019Article
- Long-term experimentalPeerJ · 2018Article
- How Environmental Factors Affect the Production of Guanidine Alkaloids by the Mediterranean Sponge Crambe crambe.Marine drugs · 2017Article
- Phakellistatins: An Underwater Unsolved Puzzle.Marine drugs · 2017Review
- Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".Marine drugs · 2016Review
- Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.Marine drugs · 2015Review
- Seasonal variation of Fatty acids and stable carbon isotopes in sponges as indicators for nutrition: biomarkers in sponges identified.Marine biotechnology (New York, N.Y.) · 2015Article
- Article
- Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria.Marine biotechnology (New York, N.Y.) · 2014Article
- Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.Marine drugs · 2014Review
- Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Mariculture and natural production of the antitumoural (+)-discodermolide by the Caribbean marine sponge Discodermia dissoluta.Marine biotechnology (New York, N.Y.) · 2013Article
- Antinociceptive activity of Stephanolepis hispidus skin aqueous extract depends partly on opioid system activation.Marine drugs · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-based sponge culture seems to be the best production method. However, for controlled production in a defined system it is better to develop in vitro production methods, like in vitro sponge culture or even better sponge cell culture, culture methods for symbionts or the transfer of production routes into another host. We still have insufficient information about the background of metabolite production in sponges. Before production methods are developed we should first focus on factors that can induce metabolite production. This could be done in the natural habitat by studying the relation between stress factors (such as predation) and the production of bioactive metabolites. The location of production within the sponge should be identified in order to choose between sponge cell culture and symbiont culture. Alternatively the biosynthetic pathways could be introduced into hosts that can be cultured. For this the biosynthetic pathway of metabolite production should be unraveled, as well as the genes involved. This review discusses the current state of sponge metabolite production and the steps that need to be taken to develop commercial production techniques. The different possible production techniques are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.