ReviewMarine drugs2009
A submarine journey: the pyrrole-imidazole alkaloids.
Review in Marine drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Synthesis, characterization,RSC advances · 2026Article
- 1-(4-Bromo-phen-yl)-4,5-diphenyl-2-(1IUCrData · 2026Article
- Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria.Natural product reports · 2025Review
- Synthesis and effect of 4-acetylphenylamine-based imidazole derivatives on migration and growth of 3D cultures of breast, prostate and brain cancer cells.Scientific reports · 2024Article
- Discovery of Anti-Inflammatory Alkaloids from SpongeMarine drugs · 2024Article
- Stonikacidin A, an Antimicrobial 4-Bromopyrrole Alkaloid Containing L-Idonic Acid Core from the Northwestern Pacific Marine SpongeMarine drugs · 2024Article
- Identification of Axinellamines A and B as Anti-Tubercular Agents.Marine drugs · 2024Article
- Pyrrole-2-carboxaldehydes: Origins and Physiological Activities.Molecules (Basel, Switzerland) · 2023Review
- Total Synthesis of (±)-Tetrahedron letters · 2023Article
- Efficient construction of the hexacyclic ring core of palau'amine: the pChemical science · 2021Article
- Marine Pyrrole Alkaloids.Marine drugs · 2021Review
- Synthesis of Agelastatin A and Derivatives Premised on a Hidden Symmetry Element Leading to Analogs Displaying Anticancer Activity.Tetrahedron · 2021Article
- Cascade synthesis of 2,4-disulfonylpyrroles by the sulfonylation/[2 + 3]-cycloaddition reactions ofRSC advances · 2021Article
- α-Aminoazoles/azines: key reaction partners for multicomponent reactions.RSC advances · 2021Review
- An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.Molecules (Basel, Switzerland) · 2020Review
- The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products.Organic chemistry frontiers : an international journal of organic chemistry · 2020Article
- In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the SpongeMarine drugs · 2020Article
- Generation and Reactivity of 2-Amido-1,3-diaminoallyl Cations: Cyclic Guanidine Annulations via Net (3 + 2) and (4 + 3) Cycloadditions.Organic letters · 2020Article
- Bromopyrrole Alkaloids from the Sponge Agelas kosrae.Marine drugs · 2018Article
- Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In his most celebrated tale "The Picture of Dorian Gray", Oscar Wilde stated that "those who go beneath the surface do so at their peril". This sentence could be a prophetical warning for the practitioner who voluntarily challenges himself with trying to synthesize marine sponge-deriving pyrrole-imidazole alkaloids. This now nearly triple-digit membered community has been growing exponentially in the last 20 years, both in terms of new representatives and topological complexity--from simple, achiral oroidin to the breathtaking 12-ring stylissadines A and B, each possessing 16 stereocenters. While the biosynthesis and the role in the sponge economy of most of these alkaloids still lies in the realm of speculations, significant biological activities for some of them have clearly emerged. This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.