ArticleMarine drugs2009
Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity.
Article in Marine drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- A closer look into the microbiome of microalgal cultures.Frontiers in microbiology · 2023Article
- Phytoplankton of the Curonian Lagoon as a New Interesting Source for Bioactive Natural Products. Special Impact on Cyanobacterial Metabolites.Biomolecules · 2021Article
- Promising Activities of Marine Natural Products against Hematopoietic Malignancies.Biomedicines · 2021Review
- Anticancer Compounds Derived from Marine Diatoms.Marine drugs · 2020Review
- Monoacylglycerides from the DiatomMarine drugs · 2019Article
- Comparing EPA production and fatty acid profiles of threeAlgal research · 2018Article
- Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.PloS one · 2018Article
- Field sampling marine plankton for biodiscovery.Scientific reports · 2017Article
- Specific Metabolites in a Phaeodactylum tricornutum Strain Isolated from Western Norwegian Fjord Water.Marine drugs · 2015Article
- Photosynthetic Pigments in Diatoms.Marine drugs · 2015Review
- Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.Marine drugs · 2014Article
- Antiviral activities and putative identification of compounds in microbial extracts from the Hawaiian coastal waters.Marine drugs · 2012Article
- Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.Marine drugs · 2010Article
- Light and temperature effects on bioactivity in diatoms.Journal of applied phycologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera Melosira, Amphora, Phaeodactylum and Nitzschia were all found to induce leukemia cell death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors of thrombin-induced blood platelet activation. Some of this activity was caused by a high content of adenosine in the diatoms, ranging from 0.07 to 0.31 microg/mg dry weight. However, most of the bioactivity was adenosine deaminase-resistant. An adenosine deaminase-resistant active fraction from one of the extracts was partially purified and shown to induce apoptosis with a distinct phenotype. The results show that benthic diatoms typically found in the intertidal zone may represent a richer source of interesting bioactive compounds than hitherto recognized.
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