ArticleThe EMBO journal1991
Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 127 citations in OpenAlex.
- Characterization and Expression of Holothurian Wnt Signaling Genes during Adult Intestinal Organogenesis.Genes · 2023Article
- An Update on the Molecular Mechanism of the Vertebrate Isthmic Organizer Development in the Context of the Neuromeric Model.Frontiers in neuroanatomy · 2022Review
- Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness.eLife · 2019Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- Wnt/β-catenin signaling during early vertebrate neural development.Developmental neurobiology · 2017Review
- Cornelia de Lange Syndrome: NIPBL haploinsufficiency downregulates canonical Wnt pathway in zebrafish embryos and patients fibroblasts.Cell death & disease · 2013Article
- Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction.Development (Cambridge, England) · 2009Article
- Mutations in the human SIX3 gene in holoprosencephaly are loss of function.Human molecular genetics · 2008Article
- Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum.Developmental biology · 2008Article
- Regulation by glycogen synthase kinase-3beta of the arborization field and maturation of retinotectal projection in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer.Development (Cambridge, England) · 2001Article
- Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes.Genome research · 1999Article
- Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- The zebrafish brain: a neuroanatomical comparison with the goldfish.Anatomy and embryology · 1996Article
- The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos.Nucleic acids research · 1994Article
- Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.The Journal of cell biology · 1993Article
- Characterization of a cell line derived from zebrafish (Brachydanio rerio) embryos.In vitro cellular & developmental biology. Animal · 1993Article
- Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development.The EMBO journal · 1993Article
- Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation.Molecular and cellular biology · 1993Article
- Diversification of the Wnt gene family on the ancestral lineage of vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt-1 (int-1) gene was originally identified as an oncogene, but its normal function is in embryogenesis. The gene is the vertebrate homologue of the Drosophila segment polarity gene wingless, and encodes a secretory protein. In mouse embryos, Wnt-1 expression is necessary for proper development of the midbrain and anterior hindbrain. Here we describe the molecular cloning and primary structure of the zebrafish Wnt-1 gene (denoted wnt-1). Comparison with its mouse homologue reveals that both the genomic organization of wnt-1 and the amino acid sequence of the corresponding gene product have been extensively conserved during vertebrate evolution. Moreover, there is probably at least one Wnt-1-related sequence in the zebrafish genome. In zebrafish embryos, wnt-1 is expressed during differentiation of the neural tube. In situ hybridization analysis reveals that the transcripts are confined to the dorsal surfaces of the midbrain, hindbrain and spinal cord, and to lateral cells at the midbrain-hindbrain junction. Thus, the pattern of wnt-1 expression in the developing central nervous system of zebrafish is virtually identical to that seen in mouse embryos. Unexpectedly, despite the striking similarities of Wnt-1 structure and expression in fish and higher vertebrates, we could not identify sequences of obvious homology outside the coding regions, neither in the promoter nor in the introns.
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