ArticleHuman reproduction (Oxford, England)2010
Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells.
Article in Human reproduction (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Circular RNA ciR-02852: A novel physiological inhibitor of Porcine ovarian granulosa cell functions.Molecular biology reports · 2026Article
- Oxytocin receptor expression in developing mouse gonads and its modulation by high-dose folic acid.Journal of molecular histology · 2025Article
- Dual Oxytocin Signals in Striatal Astrocytes.Biomolecules · 2025Article
- The Role of Oxytocin in Polycystic Ovary Syndrome: A Systematic Review.Current issues in molecular biology · 2024Review
- The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice.eLife · 2023Article
- Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses.Animals : an open access journal from MDPI · 2023Review
- The Importance of Experimental Investigation of the Peripheral Oxytocin System.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.International journal of molecular sciences · 2021Article
- A Role for HAntioxidants (Basel, Switzerland) · 2019Article
- The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.Scientific reports · 2019Article
- MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis.Reproductive biology and endocrinology : RB&E · 2019Review
- Human Luteinized Granulosa Cells-A Cellular Model for the Human Corpus Luteum.Frontiers in endocrinology · 2019Review
- Pro-nerve growth factor in the ovary and human granulosa cells.Hormone molecular biology and clinical investigation · 2015Article
- Oxytocin can decrease germ cells apoptotic index in testis under acute ischemia reperfusion in a rat model.Iranian journal of reproductive medicine · 2015Article
- Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?Cell death & disease · 2015Article
- Progesterone inhibition of oxytocin signaling in endometrium.Frontiers in neuroscience · 2013Article
- Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule.Human reproduction (Oxford, England) · 2012Article
- Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundOxytocin (OT) is produced by granulosa cells (GCs) of pre-ovulatory ovarian follicles and the corpus luteum (CL) in some mammalian species. Actions of OT in the ovary have been linked to luteinization, steroidogenesis and luteolysis. Human IVF-derived (h)GCs possess a functional OT receptor (OTR), linked to elevation of intracellular Ca(2+), but molecular identity of the receptor for OT in human granulosa cells (hGCs) and down-stream consequences are not known. METHODS AND
resultsRT-PCR, sequencing and immunocytochemistry identified the genuine OTR in hGCs. OT (10 nM-10 microM) induced elevations of intracellular Ca(2+) levels (Fluo-4 measurements), which were blocked by tocinoic acid (TA; 50 microM, a selective OTR-antagonist). Down-stream effects of OTR-activation include a concentration dependent decrease in cell viability/metabolism, manifested by reduced ATP-levels, increased caspase3/7-activity (P < 0.05) and electron microscopical signs of cellular regression. TA blocked all of these changes. Immunoreactive OTR was found in the CL and GCs of large and, surprisingly, also small pre-antral follicles of the human ovary. Immunoreactive OTR in the rhesus monkey ovary was detected in primordial and growing primary follicles in the infantile ovary and in follicles at all stages of development in the adult ovary, as well as the CL: these results were corroborated by RT-PCR analysis of GCs excised by laser capture microdissection.
conclusionsOur study identifies genuine OTRs in human and rhesus monkey GCs. Activation by high levels of OT leads to cellular regression in hGCs. As GCs of small follicles also express OTRs, OT may have as yet unknown functions in follicular development.
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