ArticleApplied and environmental microbiology2010
Polymorphic mutation frequencies of clinical and environmental Stenotrophomonas maltophilia populations.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- From nature to clinic: tracking genetic and environmental drivers of Stenotrophomonas maltophilia pathogenicity.Archives of microbiology · 2026Review
- Genomic characterization of clinical Stenotrophomonas strains from Thailand reveals five putative novel genospecies and extensive functional diversity.Scientific reports · 2026Article
- Enhanced suppression ofAntimicrobial agents and chemotherapy · 2025Article
- Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance.Nature reviews. Microbiology · 2024Review
- Enhanced Suppression ofbioRxiv : the preprint server for biology · 2024Article
- Review
- Case Report: The Conundrum of What to Pick? Antibiotic Susceptibility Variability inBritish journal of biomedical science · 2024Article
- Stenotrophomonas maltophilia: An Urgent Threat with Increasing Antibiotic Resistance.Current microbiology · 2023Review
- Comparative genomics of clinicalMicrobiology (Reading, England) · 2023Article
- The plant microbiota signature of the Anthropocene as a challenge for microbiome research.Microbiome · 2022Review
- Mutators Enhance Adaptive Micro-Evolution in Pathogenic Microbes.Microorganisms · 2022Review
- Review
- Review
- Antimicrobial susceptibility pattern ofAfrican health sciences · 2020Article
- High Genetic Diversity amongThe Malaysian journal of medical sciences : MJMS · 2018Article
- Heterogeneous Colistin-Resistance Phenotypes Coexisting inFrontiers in microbiology · 2018Article
- Contribution of increased mutagenesis to the evolution of pollutants-degrading indigenous bacteria.PloS one · 2017Article
- Evolution ofFrontiers in microbiology · 2017Article
- Prevalence of hypermutators among clinical Acinetobacter baumannii isolates.The Journal of antimicrobial chemotherapy · 2016Article
- Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria.Molecular biology and evolution · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation frequencies were studied in 174 Stenotrophomonas maltophilia isolates from clinical and nonclinical environments by detecting spontaneous rifampin-resistant mutants in otherwise-susceptible populations. The distribution of mutation frequencies followed a pattern similar to that found for other bacterial species, with a modal value of 1 x 10(-8). Nevertheless, the proportion of isolates showing mutation frequencies below the modal value (hypomutators) was significantly higher for S. maltophilia than those so far reported in other organisms. Low mutation frequencies were particularly frequent among environmental S. maltophilia strains (58.3%), whereas strong mutators were found only among isolates with a clinical origin. These results indicate that clinical environments might select bacterial populations with high mutation frequencies, likely by second-order selection processes. In several of the strong-mutator isolates, functional-complementation assays with a wild-type allele of the mutS gene demonstrated that the mutator phenotype was due to the impairment of MutS activity. In silico analysis of the amino acid changes present in the MutS proteins of these hypermutator strains in comparison with the normomutator isolates suggests that the cause of the defect in MutS might be a H683P amino acid change.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.