ArticleDiabetes care2010
Potential mediators of diabetes-related hearing impairment in the U.S. population: National Health and Nutrition Examination Survey 1999-2004.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial.Contemporary clinical trials · 2016Trial
- Imaging-identified round window niche veil and intratympanic therapy efficacy in sudden sensorineural hearing loss.Annals of medicine · 2026Article
- Castanopsis echinocarpa extract attenuates diabetes-associated peripheral-to-central auditory electrophysiological dysfunction in streptozotocin-induced diabetic mice.Metabolic brain disease · 2026Article
- Hearing Health Monitoring in Adults Living with Diabetes: A Scoping Review to Inform Integrated Care Pathways.Audiology research · 2026Review
- Identification of sensorineural hearing loss subtypes using unsupervised machine learning and assessment of their replicability.Scientific reports · 2026Article
- Self-Reported Type 2 Diabetes and the Rate of Hearing Decline in Aging.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Trends and driving factors of age-related hearing loss and severity over 30 years: a cross-sectional study.BMC geriatrics · 2025Observational
- Hearing Care Within Diabetes Care: Strategies for Direct Inclusion.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Diabetes and long duration leading to speech-, low/mid-, and high- frequency hearing loss: current evidence from the China National Health Survey 2023.Journal of endocrinological investigation · 2025Article
- Association of mixed polycyclic aromatic hydrocarbons exposure with hearing loss and the mediating role of blood cell markers of inflammation in U.S. adults.Frontiers in public health · 2024Article
- Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015-2016.Journal of multidisciplinary healthcare · 2024Article
- Jackson Heart Study: Aggregate cardiovascular disease risk and auditory profiles.Laryngoscope investigative otolaryngology · 2023Article
- Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia.Frontiers in neurology · 2022Article
- Association of inflammatory markers with hearing impairment: The English Longitudinal Study of Ageing.Brain, behavior, and immunity · 2020Article
- Evaluation and Management of Patients with Diabetes and Hearing Loss.Seminars in hearing · 2019Review
- Epidemiology of Diabetes and Hearing Loss.Seminars in hearing · 2019Review
- An Epidemiologic Study of the Association between Free Recall Dichotic Digits Test Performance and Vascular Health.Journal of the American Academy of Audiology · 2019Article
- Association between hearing organ and renal function in young adult type 1 diabetic patients: A cross-sectional study.Scientific reports · 2018Article
- Relationship of stroke risk and hearing loss in African Americans: The Jackson Heart Study.The Laryngoscope · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWe examined potential mediators of the reported association between diabetes and hearing impairment. RESEARCH DESIGN AND
methodsData come from 1,508 participants, aged 40-69 years, who completed audiometric testing during 1999-2004 in the National Health and Nutrition Examination Survey (NHANES). We defined hearing impairment as the pure-tone average >25 decibels hearing level of pure-tone thresholds at low/mid (500, 1,000, and 2,000 Hz) and high (3,000, 4,000, 6,000, and 8,000 Hz) frequencies. Using logistic regression, we examined whether controlling for vascular or neuropathic conditions, cardiovascular risk factors, glycemia, or inflammation diminished the association between diabetes and hearing impairment.
resultsDiabetes was associated with a 100% increased odds of low/mid-frequency hearing impairment (odds ratio 2.03 [95% CI 1.32-3.10]) and a 67% increased odds of high-frequency hearing impairment (1.67 [1.14-2.44]) in preliminary models after controlling for age, sex, race/ethnicity, education, smoking, and occupational noise exposure. Adjusting for peripheral neuropathy attenuated the association with low/mid-frequency hearing impairment (1.70 [1.02-2.82]). Adjusting for albuminuria and C-reactive protein attenuated the association with high-frequency hearing impairment (1.54 [1.02-2.32] and 1.50 [1.01-2.23], respectively). Diabetes was not associated with high-frequency hearing impairment after controlling for A1C (1.09 [0.60-1.99]) but remained associated with low/mid-frequency impairment. We found no evidence suggesting that our observed relationship between diabetes and hearing impairment is due to hypertension or dyslipidemia.
conclusionsMechanisms related to neuropathic or microvascular factors, inflammation, or hyperglycemia may be mediating the association of diabetes and hearing impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.