Evidence map›Paper›PMID 20097775›Full record

ArticleMolecular pharmacology2010

Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.

C Song, A Kanthasamy, V Anantharam, F Sun, A G Kanthasamy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  16. The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C SongIowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
A Kanthasamy
V Anantharam
F Sun
A G Kanthasamy
Iowa State University · US

Funding

MMT, DOPAMINERGIC DEGENERATION, AND AGINGR01ES010586 · NIEHS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2000 to 2015
$4.6M
NEUROPROTECTIVE STRATEGIES IN PARKINSONS DISEASER01NS038644 · NINDS · UNIVERSITY OF CHICAGO · PI KANTHASAMY, ANUMANTHA GOUNDER · 1999 to 2009
$2.4M
CASPASES, MITOCHONDRIAL FUNCTION AND PARKINSON'S DISEASER01NS045133 · NINDS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2003 to 2006
$1.3M
NIEHS NIH HHS ES10586NIEHS NIH HHS R01 ES010586NINDS NIH HHS NS38644NINDS NIH HHS NS45133NINDS NIH HHS R01 NS038644NINDS NIH HHS R01 NS045133
6 · The paper itself

Abstract

Pesticide exposure has been implicated in the etiopathogenesis of Parkinson's disease (PD); in particular, the organochlorine insecticide dieldrin is believed to be associated with PD. Emerging evidence indicates that histone modifications play a critical role in cell death. In this study, we examined the effects of dieldrin treatment on histone acetylation and its role in dieldrin-induced apoptotic cell death in dopaminergic neuronal cells. In mesencephalic dopaminergic neuronal cells, dieldrin induced a time-dependent increase in the acetylation of core histones H3 and H4. Histone acetylation occurred within 10 min of dieldrin exposure indicating that acetylation is an early event in dieldrin neurotoxicity. The hyperacetylation was attributed to dieldrin-induced proteasomal dysfunction, resulting in accumulation of a key histone acetyltransferase (HAT), cAMP response element-binding protein. The novel HAT inhibitor anacardic acid significantly attenuated dieldrin-induced histone acetylation, Protein kinase C delta proteolytic activation and DNA fragmentation in dopaminergic cells protected against dopaminergic neuronal degeneration in primary mesencephalic neuronal cultures. Furthermore, 30-day exposure of dieldrin in mouse models induced histone hyperacetylation in the striatum and substantia nigra. For the first time, our results collectively demonstrate that exposure to the neurotoxic pesticide dieldrin induces acetylation of core histones because of proteasomal dysfunction and that hyperacetylation plays a key role in dopaminergic neuronal degeneration after exposure of dieldrin.

Indexed as

Epigenesis, GeneticAcetylationAnacardic AcidsAnimalsAntioxidantsApoptosisCaspase 3Cells, CulturedCREB-Binding ProteinDieldrinEnvironmental PollutantsHistonesInsecticidesMaleMesencephalonMiceanacardic acidAnacardic AcidsAntioxidantsCaspase 3CREB-Binding ProteinCrebbp protein, ratDieldrinEnvironmental PollutantsHistonesInsecticidesNeuroprotective AgentsPrkcd protein, ratProteasome InhibitorsProtein Kinase C-delta

Identifiers

PMID20097775
PMCPMC2847769
OpenAlexW2114118618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.