Evidence map›Paper›PMID 20097741›Full record

ArticleEukaryotic cell2010

Effect of starvation on the endocytic pathway in Dictyostelium cells.

Ewan W Smith, Wanessa C Lima, Steve J Charette, Pierre Cosson

Abstract read
In one paragraph

Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Starvation Induces Extracellular Accumulation of Polyphosphate inInternational journal of molecular sciences · 2023
    Article
  2. Review
  3. Article
  4. Eat Prey, Live:Frontiers in immunology · 2017
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ewan W SmithDept. for Cell Physiology and Metabolism, Centre Medical Universitaire, Geneva Faculty of Medicine, 1211 Geneva 4, Switzerland.
Wanessa C Lima
Steve J Charette
Pierre Cosson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dictyostelium discoideum amoebae have been used extensively to study the structure and dynamics of the endocytic pathway. Here, we show that while the general structure of the endocytic pathway is maintained in starved cells, its dynamics rapidly slow down. In addition, analysis of apm3 and lvsB mutants reveals that the functional organization of the endocytic pathway is profoundly modified upon starvation. Indeed, in these mutant cells, some of the defects observed in rich medium persist in starved cells, notably an abnormally slow transfer of endocytosed material between endocytic compartments. Other parameters, such as endocytosis of the fluid phase or the rate of fusion of postlysosomes to the cell surface, vary dramatically upon starvation. Studying the endocytic pathway in starved cells can provide a different perspective, allowing the primary (invariant) defects resulting from specific mutations to be distinguished from their secondary (conditional) consequences.

Indexed as

Adaptor Protein Complex mu SubunitsCulture MediaDictyosteliumEndocytosisExocytosisFood DeprivationKineticsLysosomesMembrane FusionPhagocytosisPinocytosisProtozoan ProteinsStress, PhysiologicalTransport VesiclesVesicular Transport ProteinsAdaptor Protein Complex mu SubunitsCulture MediaProtozoan ProteinsVesicular Transport Proteins

Identifiers

PMID20097741
PMCPMC2837978

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.