ArticleEukaryotic cell2010
Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in Candida albicans.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 78 citations in OpenAlex.
- An emergent biofilm program from inactivation of Candida albicans master regulators Efg1 and Ndt80.PLoS pathogens · 2026Article
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- Ndt80 Orchestrates Copper Stress Responses and Mitochondrial Homeostasis inJournal of fungi (Basel, Switzerland) · 2026Article
- Profound cell wall remodeling inMicrobiology spectrum · 2026Article
- Antifungal activities of Equol againstVirulence · 2024Article
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- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Genetic Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
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- Selection of Ethanol Tolerant Strains ofbioRxiv : the preprint server for biology · 2023Article
- Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2023Article
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- The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes.Virulence · 2021Article
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- Review
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- Transcriptional Control of Hypoxic Hyphal Growth in the Fungal PathogenFrontiers in cellular and infection microbiology · 2021Article
- A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans.Nature communications · 2020Article
- Transcriptional control of hyphal morphogenesis in Candida albicans.FEMS yeast research · 2020Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The NDT80/PhoG transcription factor family includes ScNdt80p, a key modulator of the progression of meiotic division in Saccharomyces cerevisiae. In Candida albicans, a member of this family, CaNdt80p, modulates azole sensitivity by controlling the expression of ergosterol biosynthesis genes. We previously demonstrated that CaNdt80p promoter targets, in addition to ERG genes, were significantly enriched in genes related to hyphal growth. Here, we report that CaNdt80p is indeed required for hyphal growth in response to different filament-inducing cues and for the proper expression of genes characterizing the filamentous transcriptional program. These include noteworthy genes encoding cell wall components, such as HWP1, ECE1, RBT4, and ALS3. We also show that CaNdt80p is essential for the completion of cell separation through the direct transcriptional regulation of genes encoding the chitinase Cht3p and the cell wall glucosidase Sun41p. Consistent with their hyphal defect, ndt80 mutants are avirulent in a mouse model of systemic candidiasis. Interestingly, based on functional-domain organization, CaNdt80p seems to be a unique regulator characterizing fungi from the CTG clade within the subphylum Saccharomycotina. Therefore, this study revealed a new role of the novel member of the fungal NDT80 transcription factor family as a regulator of cell separation, hyphal growth, and virulence.
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