ArticleJournal of the Royal Society, Interface2010
Switchable genetic oscillator operating in quasi-stable mode.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Tractable nonlinear memory functions as a tool to capture and explain dynamical behaviors.Physical review research · 2020Article
- Engineered signal-coupled inducible promoters: measuring the apparent RNA-polymerase resource budget.Nucleic acids research · 2020Article
- Basal leakage in oscillation: Coupled transcriptional and translational control using feed-forward loops.PLoS computational biology · 2020Article
- Oscillations in well-mixed, deterministic feedback systems: Beyond ring oscillators.Journal of theoretical biology · 2019Article
- Article
- Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks.Journal of the Royal Society, Interface · 2018Article
- Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.Cell systems · 2018Article
- Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case.BMC systems biology · 2016Article
- Multi-stable dynamics of the non-adiabatic repressilator.Journal of the Royal Society, Interface · 2015Article
- Synthesising periodic triggering signals with genetic oscillators.IET systems biology · 2014Article
- Tuning the dials of Synthetic Biology.Microbiology (Reading, England) · 2013Review
- Design of synthetic genetic oscillators using evolutionary optimization.Evolutionary bioinformatics online · 2013Article
- Article
- Article
- Bayesian design strategies for synthetic biology.Interface focus · 2011Article
- A comparative analysis of synthetic genetic oscillators.Journal of the Royal Society, Interface · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behaviour in transient and stochastic environments such as the cell. We show here that even repressilators possess quasi-stable, travelling wave periodic solutions that are reachable, long-lived and robust to parameter changes. These solutions underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches. The existence of such solutions can also be exploited for control purposes: operation of the system around the quasi-stable orbit allows us to turn on and off the oscillations reliably and on demand. We illustrate these ideas with a simple protocol based on optical interference that can induce oscillations robustly both in the stochastic and deterministic regimes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.