ArticleEuropean heart journal2010
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
Article in European heart journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Anxiety and prognosis of patients with myocardial infarction: A meta-analysis.Clinical cardiology · 2021Pooled it
- AA in Brain-Memory, Dementia, Depression, Anxiety, Alzheimer's Disease, Affective and Psychiatric Disorders, and Coronary Heart Disease (CHD).Reviews of physiology, biochemistry and pharmacology · 2027Review
- Role of Depression and Anxiety in Peripheral Artery Disease: Correlates, Outcomes, and Considerations for Treatment.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder.BMC psychiatry · 2024Article
- Improving Cardiovascular Disease Prediction With Machine Learning Using Mental Health Data: A Prospective UK Biobank Study.JACC. Advances · 2024Article
- Association of Depression and Anxiety with Cardiac Structural and Functional Characteristics in Heart Failure with Reduced and Mildly Reduced Ejection Fraction.Clinics and practice · 2023Article
- Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.Journal of clinical laboratory analysis · 2021Article
- Effects of clinical depression on left ventricular dysfunction in patients with acute coronary syndrome.Journal of thrombosis and thrombolysis · 2021Article
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Association between anxiety and clinical outcomes in Chinese patients with myocardial infarction in the absence of obstructive coronary artery disease.Clinical cardiology · 2020Article
- Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation.European heart journal · 2020Article
- Elevated neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict post-stroke depression with acute ischemic stroke.Experimental and therapeutic medicine · 2020Article
- Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea.BMJ open · 2019Article
- Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression.Psychosomatic medicine · 2019Article
- Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation.European heart journal · 2018Article
- Susceptibility to chronic social stress increases plaque progression, vulnerability and platelet activation.Thrombosis and haemostasis · 2017Article
- Risk of anxiety and depressive disorders in patients with myocardial infarction: A nationwide population-based cohort study.Medicine · 2016Article
- Observational
- Anxiety, Depression, and General Psychological Distress in Patients with Coronary Slow Flow.Arquivos brasileiros de cardiologia · 2015Article
- Platelet response to serotonin in patients with stable coronary heart disease.The American journal of cardiology · 2014Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
aimsDepression and anxiety are linked to coronary events but the mechanism(s) remains unclear. We investigated the associations of depression and anxiety with serotonin-mediated platelet hyperactivity in coronary artery disease (CAD) patients in a cross-sectional study. METHODS AND
resultsThree months after an acute coronary event, stable CAD patients (n = 83) on aspirin and clopidogrel were evaluated for depression (beck depression inventory) and anxiety (hospital anxiety and depression scale), and their platelet reactivity was measured (optical aggregometry and flow cytometric fibrinogen binding in response to adenosine diphosphate (ADP = 5 microM) and two serotonin + epinephrine doses [5HT:E (L) = 4 microM + 4 microM and 5HT:E (H) = 10 microM + 4 microM]. Platelet reactivity was significantly higher in depressed and anxious than in depressed only or non-depressed-and-non-anxious patients. Aggregation (mean +/- SE) was 41.9 +/- 2.6% vs. 32.2 +/- 2.6% vs. 30.4 +/- 3.7% with 5HT:E (L) and 46.9 +/- 2.7% vs. 35.6 +/- 2.7% vs. 31.7 +/- 3.8% with 5HT:E (H) (P < 0.05 for both). Differences in ADP aggregations were not significant, perhaps because of clopidogrel therapy. Flow cytometry findings were similar. In a multivariate linear regression model adjusted for age, body mass index, and each other, anxiety symptoms independently predicted all 5HT:E-mediated platelet reactivity measures, whereas depression predicted none.
conclusionAnxiety is associated with elevated serotonin-mediated platelet reactivity in stable CAD patients and symptoms of anxiety show strong, independent correlations with platelet function.
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