ArticleThe Journal of urology2010
Effect of estrogen on bladder nociception in rats.
Article in The Journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats.Biology of sex differences · 2020Article
- Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats.The journal of pain · 2018Article
- Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain.Translational psychiatry · 2016Review
- Urine Trouble: Alterations in Brain Function Associated with Bladder Pain.The Journal of urology · 2016Review
- A clinically relevant animal model of temporomandibular disorder and irritable bowel syndrome comorbidity.The journal of pain · 2014Article
- Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones.World journal of gastroenterology · 2014Review
- Sex differences and hormonal modulation of deep tissue pain.Frontiers in neuroendocrinology · 2013Review
- Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.The journal of pain · 2012Article
- Effects of acute adult and early-in-life bladder inflammation on bladder neuropeptides in adult female rats.BMC urology · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe assessed the effect of ovariectomy and estrogen replacement on nociceptive responses to bladder distention in a rat model. MATERIALS AND
methodsFemale Sprague-Dawley rats (Harlan) underwent ovariectomy or sham surgery. Visceromotor responses (abdominal contractions) to bladder distention were determined 3 to 4 weeks later under isoflurane anesthesia. In rat subsets estrogen was chronically replaced with a subcutaneous estrogen pellet vs a placebo pellet or acutely replaced by subcutaneous injection 24 hours before testing. Effects of estrogen withdrawal were examined in another group of rats by implanting a pellet and explanting the pellet 24 hours before testing. Uterine weight was measured to assess the estrogen dose.
resultsVisceromotor responses to bladder distention were significantly less vigorous in ovariectomized rats vs controls. Acute estrogen replacement increased visceromotor responses in these rats but chronic estrogen replacement did not. Sudden chronic estrogen withdrawal resulted in increased visceromotor responses. Uterine weight was consistent with the physiological estrogen dose.
conclusionsEstrogen alone was not sufficient to produce increased nociceptive responses but an acute decrease in estrogen resulted in increased visceromotor responses. These data suggest that the pronociceptive effects of estrogen may be due to a mismatch between peripheral vs central and/or genomic vs nongenomic effects of the hormone, which occur during rapidly decreasing estrogen levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.