ReviewDrug discovery today2010
Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.
Review in Drug discovery today, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Mothra: MultiobjectiveJournal of chemical information and modeling · 2024Article
- Development of an extended action fostemsavir lipid nanoparticle.Communications biology · 2024Article
- Gargoyles: An Open Source Graph-Based Molecular Optimization Method Based on Deep Reinforcement Learning.ACS omega · 2023Article
- Discovery of a HiddenACS omega · 2023Article
- Applications of artificial intelligence to drug design and discovery in the big data era: a comprehensive review.Molecular diversity · 2021Review
- Advances in de Novo Drug Design: From Conventional to Machine Learning Methods.International journal of molecular sciences · 2021Review
- Advantages of Structure-Based Drug Design Approaches in Neurological Disorders.Current neuropharmacology · 2017Review
- Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target.Scientific reports · 2015Article
- The (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids Inhibit the HIV-1 Reverse Transcriptase.Lipids · 2015Article
- Substituent effects on molecular properties of dicarba-closo-dodecarborane derivatives.Journal of molecular modeling · 2014Article
- Article
- Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase.Marine drugs · 2013Article
- Density functional theory study of the local molecular properties of acetamide derivatives as anti-HIV drugs.Research in pharmaceutical sciences · 2013Article
- From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-Festinavir.Current pharmaceutical design · 2013Review
- Correlation between biological activity and binding energy in systems of integrin with cyclic RGD-containing binders: a QM/MM molecular dynamics study.Journal of molecular modeling · 2012Article
- Design, practical synthesis, and biological evaluation of novel 6-(pyrazolylmethyl)-4-quinoline-3-carboxylic acid derivatives as HIV-1 integrase inhibitors.Molecules (Basel, Switzerland) · 2012Article
- Computational drug discovery.Acta pharmacologica Sinica · 2012Review
- Identification of HIV inhibitors guided by free energy perturbation calculations.Current pharmaceutical design · 2012Review
- Cyclodepsipeptides from marine sponges: natural agents for drug research.Marine drugs · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhibitors that interact specifically with targets besides transcriptase and protease. This review presents details of the anti-HIV inhibitors discovered with computer-aided approaches and provides an overview of the recent five-year achievements in the treatment of HIV infection and the application of computational methods to current drug design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.