ArticlePhysiology & behavior2010
Operant responding for sucrose by rats bred for high or low saccharin consumption.
Article in Physiology & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of naltrexone on amphetamine choice in rhesus monkeys and rats.Experimental and clinical psychopharmacology · 2023Article
- Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues.Brain sciences · 2022Review
- Sweet taste pleasantness is modulated by morphine and naltrexone.Psychopharmacology · 2016Article
- Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake.Behavioural pharmacology · 2016Article
- Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding.Drug development research · 2015Article
- Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.Alcoholism, clinical and experimental research · 2015Review
- Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC).Behavioural processes · 2015Article
- Cocaine withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake.Pharmacology, biochemistry, and behavior · 2015Article
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
- Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring tested in a brief-access taste procedure.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Double-dissociation of D1 and opioid receptor antagonism effects on the acquisition of sucrose-conditioned flavor preferences in BALB/c and SWR mice.Pharmacology, biochemistry, and behavior · 2012Article
- Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake.Neuroscience letters · 2012Article
- Sweet success, bitter defeat: a taste phenotype predicts social status in selectively bred rats.PloS one · 2012Article
- Regulation of drug and palatable food overconsumption by similar peptide systems.Current drug abuse reviews · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The use of rats differing in the intake of sweet substances has highlighted some interesting parallels between taste preferences and drug self-administration. For example, rats selectively bred to consume high (HiS) or low (LoS) amounts of a 0.1% saccharin solution (when compared to water consumption), show corresponding differences across several measures of cocaine self-administration (HiS>LoS). In this study, we measured whether the two strains also differ when response requirements are imposed for obtaining a sucrose reinforcer. Male HiS and LoS rats were measured for operant responding for sucrose pellets under fixed-ratio (FR) schedules of 1, 3, 5 and 10 and under a progressive-ratio (PR) schedule, during which the response requirement for each successive pellet increased exponentially. The effect of systemic naltrexone (0.3, 1 and 3mg/kg) on PR responding for sucrose pellets was also tested. Under all FR and PR schedules, the number of pellets obtained by the LoS rats were significantly lower than those obtained by the HiS rats. Although the LoS weighed more than the HiS rats, this difference does not appear to explain differences in operant behavior. No strain differences in the effect of naltrexone were observed; the 3mg/kg dose reduced the number of pellets obtained in both strains. Measures of locomotor activity taken prior to operant trials suggest that the differences in responding were not due to differences in general activity levels. These studies provide further characterization of the HiS and LoS rat lines by demonstrating that motivation to consume sucrose is greater in HiS than in LoS rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.