ArticleCurrent biology : CB2010
Roles of dopamine in circadian rhythmicity and extreme light sensitivity of circadian entrainment.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 82 citations in OpenAlex.
- Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.Parasites & vectors · 2025Article
- Drug discovery and development for Parkinson's disease: are preclinical models good enough?Frontiers in aging neuroscience · 2025Review
- Evidence of separate influence of moon and sun on light synchronization of mussel's daily rhythm during the polar night.iScience · 2023Article
- Motivational and Valence-Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Two light sensors decode moonlight versus sunlight to adjust a plastic circadian/circalunidian clock to moon phase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Compartment specific regulation of sleep by mushroom body requires GABA and dopaminergic signaling.Scientific reports · 2021Article
- Photophysiological cycles in Arctic krill are entrained by weak midday twilight during the Polar Night.PLoS biology · 2021Article
- Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Study on the Sleep-Improvement Effects ofFoods (Basel, Switzerland) · 2021Article
- Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons.Journal of Parkinson's disease · 2021Article
- Circadian Responses to Light-Flash Exposure: Conceptualization and New Data Guiding Future Directions.Frontiers in neurology · 2021Article
- Timing of male territorial flight and foraging of the large carpenter bee Xylocopa appendiculata related to serotonin in the brain.Die Naturwissenschaften · 2020Article
- Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.Neuron · 2019Article
- An inexpensive air stream temperature controller and its use to facilitate temperature-controlled behavior in Drosophila.BioTechniques · 2019Article
- Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back.International journal of molecular sciences · 2018Review
- Article
- Calcium and cAMP directly modulate the speed of the Drosophila circadian clock.PLoS genetics · 2018Article
- Abnormal visual gain control and excitotoxicity in early-onset Parkinson's disease Drosophila models.Journal of neurophysiology · 2018Article
- Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock inFrontiers in molecular neuroscience · 2018Article
- Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes.Neurobiology of disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Light has profound behavioral effects on almost all animals, and nocturnal animals show sensitivity to extremely low light levels [1-4]. Crepuscular, i.e., dawn/dusk-active animals such as Drosophila melanogaster are thought to show far less sensitivity to light [5-8]. Here we report that Drosophila respond to extremely low levels of monochromatic blue light. Light levels three to four orders of magnitude lower than previously believed impact circadian entrainment and the light-induced stimulation of locomotion known as positive behavioral masking. We use GAL4;UAS-mediated rescue of tyrosine hydroxylase (DTH) mutant (ple) flies to study the roles of dopamine in these processes. We present evidence for two roles of dopamine in circadian behaviors. First, rescue with either a wild-type DTH or a DTH mutant lacking neural expression leads to weak circadian rhythmicity, indicating a role for strictly regulated DTH and dopamine in robust circadian rhythmicity. Second, the DTH rescue strain deficient in neural dopamine selectively shows a defect in circadian entrainment to low light, whereas another response to light, positive masking, has normal light sensitivity. These findings imply separable pathways from light input to the behavioral outputs of masking versus circadian entrainment, with only the latter dependent on dopamine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.