Evidence map›Paper›PMID 20096285›Full record

ReviewJournal of molecular and cellular cardiology2010

Electrophysiological remodeling in heart failure.

Yanggan Wang, Joseph A Hill

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Trial
  2. Article
  3. Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β-Adrenoceptor Stimulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Vectorcardiography Predicts Heart Failure in Patients Following ST Elevation Myocardial Infarction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Overview of Cardiac Arrhythmias and Treatment Strategies.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yanggan WangDepartment of Pediatrics, Emory University, Atlanta, GA, USA. yanggan.wang@emory.edu
Joseph A Hill

Funding

HDAC Inhibition in Cardiac Hypertrophy and FailureR01HL080144 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2007 to 2011
$2.0M
Calcineurin-Mediated Regulation of Cardiac Ca2+ ChannelR01HL075173 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2005 to 2009
$1.7M
Foxo: Negative Regulator of Cardiac HypertrophyR01HL090842 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2012
$1.6M
Functional Genomics of Complex Vascular DiseaseP30HL101254 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2010
$1.3M
Functional Coupling between Ito and ICa in CardiomyocytesR01HL083271 · NHLBI · EMORY UNIVERSITY · PI WANG, YANGGAN · 2009 to 2010
$775k
Physical and functional coupling between transient outward K+ channel and CaMKIIR21HL088168 · NHLBI · EMORY UNIVERSITY · PI WANG, YANGGAN · 2007 to 2008
$427k
NHLBI NIH HHS HL-075173NHLBI NIH HHS HL-080144NHLBI NIH HHS HL083271NHLBI NIH HHS HL-088168NHLBI NIH HHS HL-090842NHLBI NIH HHS P30 HL101254NHLBI NIH HHS R01 HL075173NHLBI NIH HHS R01 HL080144NHLBI NIH HHS R01 HL083271NHLBI NIH HHS R01 HL090842NHLBI NIH HHS R21 HL088168
6 · The paper itself

Abstract

Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.

Indexed as

AnimalsAnisotropyArrhythmias, CardiacAtrioventricular NodeElectrophysiologyGap JunctionsHeartHeart FailureHumansMyocardial ContractionMyocardiumPotassiumPurkinje CellsRatsPotassium

Identifiers

PMID20096285
PMCPMC2879059

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.