Trial reportEuropean radiology2010
Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla.
Trial report in European radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis--establishing disease prognosis and monitoring patients.Nature reviews. Neurology · 2015Guideline
- Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.Nature reviews. Neurology · 2015Guideline
- A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research.European radiology · 2012Pooled it
- MS cortical lesions on DIR: not quite what they seem?PloS one · 2013Trial
- Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double Inversion Recovery MR Imaging with Deep Learning-based Reconstruction.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- The corticospinal tract in multiple sclerosis: correlation between cortical excitability and magnetic resonance imaging measures.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis.Biomedicines · 2022Review
- Neuroimaging at 7 Tesla: a pictorial narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Detection of multiple sclerosis lesions in the cervical cord: which of the MAGNIMS 'mandatory' non-gadolinium enhanced sagittal sequences is optimal at 3T?The neuroradiology journal · 2021Article
- Neural Underpinnings of Proactive Interference in Working Memory: Evidence From Patients With Unilateral Lesions.Frontiers in neurology · 2021Article
- Voxel-based morphometry analysis of double inversion-recovery magnetic resonance imaging for detecting microscopic lesions: a simulation study.Radiological physics and technology · 2019Article
- Post-Mortem MRI and Histopathology in Neurologic Disease: A Translational Approach.Neuroscience bulletin · 2019Review
- Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Development of Cortical Lesion Volumes on Double Inversion Recovery MRI in Patients With Relapse-Onset Multiple Sclerosis.Frontiers in neurology · 2019Article
- MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course.Brain pathology (Zurich, Switzerland) · 2018Article
- Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study.Neurology · 2018Article
- Magnetic Resonance Imaging in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2018Review
- The current role of MRI in differentiating multiple sclerosis from its imaging mimics.Nature reviews. Neurology · 2018Review
- Pre- and Postcontrast 3D Double Inversion Recovery Sequence in Multiple Sclerosis: A Simple and Effective MR Imaging Protocol.AJNR. American journal of neuroradiology · 2017Article
- Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 2-Surveillance for Treatment Complications and Disease Progression.AJNR. American journal of neuroradiology · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS) patients, in particular using a dedicated double inversion recovery (DIR) pulse sequence.
methodsThirty-four patients with clinically isolated syndromes or definite MS were included. All patients underwent magnetic resonance imaging (MRI) at 1.5 T and 3 T, including T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR) and DIR sequences. All images were analysed for focal lesions categorised according to their anatomical location.
resultsThe total number of detected lesions was higher at 3 T across all pulse sequences. We observed significantly higher numbers of lesions involving the cortex at 3 T using a DIR sequence. DIR at 3 T showed 192% more pure intracortical (p < 0.001) and 30% more mixed grey matter-white matter lesions (p = 0.008). No significant increase in cortical lesions could be detected on the FLAIR and T2-weighted images. Using the T2-weighted and FLAIR sequences, significantly more lesions could be detected at 3 T in the infratentorial, periventricular and juxtacortical white matter.
conclusionDIR brain MR imaging at 3 T substantially improves the sensitivity of the detection of cortical lesions compared with the standard magnetic field strength of 1.5 T.
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