ReviewJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
The impact of intestinal failure on oral drug absorption: a review.
Review in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05302531 (Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Systematic review of drug bioavailability following gastrointestinal surgery.European journal of clinical pharmacology · 2018Pooled it
- Seasonal Prevalence, Molecular Identification and Therapeutic Management of Enterotoxemia Caused by Clostridium perfringens Type D in Goats of Peshawar and Charsadda Districts, Pakistan.Veterinary medicine and science · 2026Article
- Crohn's disease exacerbated by ghost pills of upadacitinib.Clinical journal of gastroenterology · 2025Article
- Oral antimicrobial agents in patients with short bowel syndrome: worth a try!The Journal of antimicrobial chemotherapy · 2023Article
- Getting the OK to Import Zero K MVI: Maintaining TTR in an Infant with SBS.Digestive diseases and sciences · 2020Article
- Pathophysiology and management of diabetic gastroenteropathy.Therapeutic advances in gastroenterology · 2019Review
- A fast screening model for drug permeability assessment based on native small intestinal extracellular matrix.RSC advances · 2018Article
- Improvement of paracellular transport in the Caco-2 drug screening model using protein-engineered substrates.Biomaterials · 2017Article
- Characterizing drug-metabolizing enzymes and transporters that areActa pharmaceutica Sinica. B · 2016Article
- Biomagnetic methods: technologies applied to pharmaceutical research.Pharmaceutical research · 2011Review
- Therapeutic Drug Monitoring of Anti-human Immunodeficiency Virus Drugs in a Patient with Short Bowel Syndrome.Internal medicine (Tokyo, Japan)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntestinal failure is a complex gastroenterological condition that occurs as a result of reduced intestinal absorption of nutrients and/or water and electrolytes. Without treatment, nutritional depletion and/or dehydration will result. It can be acute or chronic and occurs secondary to a variety of causes, including massive bowel resection, inflammatory bowel diseases of the bowel, and small bowel dysfunction. RESULTS AND DISCUSSION: Resection of the small bowel results in a range of physiological changes that affect the absorption of nutrients, water, and electrolytes. In addition, these changes may also affect the absorption of orally administered medication. However, there is only minimal published literature regarding this, with the publications limited to case reports of failure or efficacy of certain medicines such as digoxin and warfarin in individual patients. Due to the highly heterogeneous nature of intestinal failure patients, there is little generalizability of the information within these articles to other patients. Only one article seeks to provide limited practical advice regarding prescribing in this complex patient group.
conclusionThe input of specialist pharmacists is necessary in the management of these patients to ensure that appropriate drugs and formulations are prescribed in a timely manner to optimize absorption and resultant efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.