ArticleDigestive diseases and sciences2010
Association of HLA-DR14 with the treatment response in Japanese patients with autoimmune hepatitis.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Autoimmune Hepatitis in the Asia-Pacific Area.Journal of clinical and translational hepatology · 2018Review
- Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis.BMC gastroenterology · 2015Article
- Genetic background of autoimmune hepatitis in Japan.Journal of gastroenterology · 2011Article
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15 authors at 2 institutions in 1 country.
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Abstract
backgroundInfluence of human lymphocyte antigen (HLA) on the therapeutic response in autoimmune hepatitis (AIH) is not known.
aimsTo evaluate if HLA-DR types influence biological and histological responses to corticosteroids in patients with AIH.
methodsDuring 28 years from 1979 through 2007, 48 patients with definite diagnosis of AIH received long-term corticosteroid therapy (median 9 years [range: 5-28 years]) in a single Japanese center. They were followed for transaminase levels and received liver biopsy before and after the treatment.
resultsDR4 was detected in 32 and DR14 in 11 patients; seven possessed both DR4 and DR14. DR4 was more frequent in AIH patients than in the general population (67% vs. 22%), while DR14 was comparably frequent between them (23% vs. 17%). Overall, biochemical response was achieved in 43 (90%) of the 48 patients. The sustained biochemical response to a maintenance prednisolone dose < 10 mg was gained more frequently in the patients with than without DR14 (10/11 [91%] vs. 10/37 [27%], P < 0.001). Marked histological improvement with a decrease in histology activity index (HAI) score by > 2 points was achieved in 31 of the 32 (97%) biochemical responders. Histological aggravation with an increase in HAI score occurred in 4 of the 16 (25%) patients without biochemical response (non-responders and relapsers combined), but in none of the 32 responders.
conclusionLong-term immunosuppressive treatment can improve the outcome of Japanese patients with AIH, and DR14 is associated with excellent biochemical response.
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