ArticleImmunogenetics2010
Study of cynomolgus monkey (Macaca fascicularis) DRA polymorphism in four populations.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Divergence between genes but limited allelic polymorphism in two MHC class II A genes in Leach's storm-petrels Oceanodroma leucorhoa.Immunogenetics · 2019Article
- Review
- Comparative immunity of antigen recognition, differentiation, and other functional molecules: similarities and differences among common marmosets, humans, and mice.Experimental animals · 2018Review
- Identification of MHC Haplotypes Associated with Drug-induced Hypersensitivity Reactions in Cynomolgus Monkeys.Toxicologic pathology · 2017Article
- Novel DRA alleles extracted from seven macaque cohorts.Tissue antigens · 2015Article
- Study of MHC class II region polymorphism in the Filipino cynomolgus macaque population.Immunogenetics · 2014Article
- Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model.Immunogenetics · 2014Article
- Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia.PloS one · 2014Article
- Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques.Immunogenetics · 2013Article
- Comprehensive identification of high-frequency and co-occurring Mafa-DPA1, Mafa-DQA1, Mafa-DRA, and Mafa-DOA alleles in Vietnamese cynomolgus macaques.Immunogenetics · 2013Article
- Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations.Immunogenetics · 2012Article
- Identification of polymorphisms in genes of the immune system in cynomolgus macaques.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome.Immunogenetics · 2012Article
- Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques.Immunogenetics · 2011Article
- Impact of MHC class II polymorphism on blood counts of CD4+ T lymphocytes in macaque.Immunogenetics · 2011Article
- Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region.Immunogenetics · 2011Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not been described until now. In the Mauritius population, we confirmed the presence of three DRA alleles. In the Philippine and Vietnam populations, we observed 11 and 14 DRA alleles, respectively. Only two alleles were present in all three populations. All DRA alleles but one differ from the consensus sequence by one to three mutations, most being synonymous; so, only seven DR alpha proteins were deduced from the 22 cDNA alleles. One DRA cDNA allele, Mafa-DRA*02010101, differs from all other alleles by 11 to 14 mutations of which only four are non-synonymous. The two amino acid changes inside the peptide groove of Mafa-DRA*02010101 are highly conservative. The very low proportion of non-synonymous/synonymous mutations is compatible with a purifying selection which is comparable to all previous observations concerning the evolution of the DRA gene in mammals. Homologues of the allele Mafa-DRA*02010101 are also found in two other Asian macaques (Macaca mulatta and Macaca nemestrina). The forces able to maintain this highly divergent allele in three different macaque species remain hypothetical.
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