ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Evidence for peripheral and central actions of codeine to dysregulate swallowing in the anesthetized cat.Frontiers in neurology · 2024Article
- Cough hypersensitivity and chronic cough.Nature reviews. Disease primers · 2022Review
- Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat.Frontiers in physiology · 2021Article
- Essential Role of the cVRG in the Generation of Both the Expiratory and Inspiratory Components of the Cough Reflex.Physiological research · 2020Review
- Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat.Physiological research · 2020Article
- GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.Respiratory physiology & neurobiology · 2018Article
- Central adenosine ABritish journal of pharmacology · 2018Article
- Role of the dorsomedial medulla in suppression of cough by codeine in cats.Respiratory physiology & neurobiology · 2017Article
- Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.Journal of neurophysiology · 2017Article
- The course of lung inflation alters the central pattern of tracheobronchial cough in cat-The evidence for volume feedback during cough.Respiratory physiology & neurobiology · 2016Article
- Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Role of the dorsal medulla in the neurogenesis of airway protection.Pulmonary pharmacology & therapeutics · 2015Review
- Central administration of nicotine suppresses tracheobronchial cough in anesthetized cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Review
- Central neural circuits for coordination of swallowing, breathing, and coughing: predictions from computational modeling and simulation.Otolaryngologic clinics of North America · 2013Article
- Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit.Physiological reports · 2013Article
- Modulation of the cough reflex by GABA(A) receptors in the caudal ventral respiratory group of the rabbit.Frontiers in physiology · 2012Article
- Central antitussive effect of codeine in the anesthetized rabbit.European journal of medical research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigated the influence of microinjection of codeine into the caudal ventral respiratory column (cVRC) on the cough reflex. Experiments were performed on 36 anesthetized spontaneously breathing cats. Electromyograms (EMGs) were recorded bilaterally from inspiratory parasternal and expiratory transversus abdominis (ABD) muscles and unilaterally from laryngeal posterior cricoarytenoid and thyroarytenoid muscles. Repetitive coughing was elicited by mechanical stimulation of the intrathoracic airways. The unilateral microinjection of codeine (3.3 mM, 20-32 nl) in the cVRC reduced cough number by 29% (P < 0.01) and expiratory cough amplitudes of esophageal pressure by 33% (P < 0.05) as well as both ipsilateral and contralateral ABD EMGs by 35% and 48% (P < 0.01 and P < 0.01, respectively). No cough depression was observed after microinjections of vehicle. There was no significant effect of microinjection of codeine in the cVRC (3.3 mM, 30-40 nl) on ABD activity induced by a microinjection of D,L-homocysteic acid (30 mM, 27-40 nl) in the same location. However, a cumulative dose of codeine (0.1 mg/kg, 330 nmol/kg) applied into the brain stem circulation through the vertebral artery reduced the ABD motor response to cVRC D,L-homocysteic acid microinjection (30 mM, 28-32 nl) by 47% (P < 0.01). These results suggest that 1) codeine can act within the cVRC to suppress cough and 2) expiratory premotoneurons within the cVRC are relatively insensitive to this opioid.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.