ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
CO2 chemoreception in cardiorespiratory control.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Quantifying ventilatory control with 3% CO2 inhalation during exercise.Frontiers in physiology · 2025Article
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Locus Coeruleus Acid-Sensing Ion Channels Modulate Sleep-Wakefulness and State Transition from NREM to REM Sleep in the Rat.Neuroscience bulletin · 2021Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats.Neuroscience · 2016Article
- Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update.Translational psychiatry · 2015Review
- A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.PloS one · 2015Article
- A HCO(3)(-)-dependent mechanism involving soluble adenylyl cyclase for the activation of Ca²⁺ currents in locus coeruleus neurons.Biochimica et biophysica acta · 2014Article
- Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals.Frontiers in cellular neuroscience · 2014Review
- Transient outwardly rectifying A currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Postnatal development and activation of L-type Ca2+ currents in locus ceruleus neurons: implications for a role for Ca2+ in central chemosensitivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.The Journal of physiology · 2012Article
- Central chemoreceptors: locations and functions.Comprehensive Physiology · 2012Review
- Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.PloS one · 2012Article
- Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.Journal of neurophysiology · 2011Article
- Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.The Journal of biological chemistry · 2011Article
- Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Considerable progress has been made elucidating the cellular signals and ion channel targets involved in the response to increased CO2/H+ of brain stem neurons from chemosensitive regions. Intracellular pH (pHi) does not exhibit recovery from an acid load when extracellular pH (pHo) is also acid. This lack of pHi recovery is an essential but not unique feature of all chemosensitive neurons. These neurons have pH-regulating transporters, especially Na+/H+ exchangers, but some may also contain HCO3--dependent transporters as well. Studies in locus ceruleus (LC) neurons have shown that firing rate will increase in response to decreased pHi or pHo but not in response to increased CO2 alone. A number of K+ channels, as well as other channels, have been suggested to be targets of these pH changes with a fall of pH inhibiting these channels. In neurons from some regions it appears that multiple signals and multiple channels are involved in their chemosensitive response while in neurons from other regions a single signal and/or channel may be involved. Despite the progress, a number of key issues remain to be studied. A detailed study of chemosensitive signaling needs to be done in neurons from more brain stem regions. Fully describing the chemosensitive signaling pathways in brain stem neurons will offer new targets for therapies to alter the strength of central chemosensitivity and will yield new insights into the reason why there are multiple central chemoreceptive sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.