ArticleRadiology2010
Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementia.
Article in Radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities.The Journal of infectious diseases · 2018Trial
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- More than one-half of the variance in in vivo proton MR spectroscopy metabolite estimates is common to all metabolites.NMR in biomedicine · 2023Article
- A Neurometabolic Pattern of Elevated Myo-Inositol in Children Who Are HIV-Exposed and Uninfected: A South African Birth Cohort Study.Frontiers in immunology · 2022Article
- MR spectroscopy in HIV associated neurocognitive disorder in the era of cART: a review.AIDS research and therapy · 2021Review
- Evolving White Matter Injury following Pediatric Traumatic Brain Injury.Journal of neurotrauma · 2021Article
- Motion correction in magnetic resonance spectroscopy.Magnetic resonance in medicine · 2020Review
- Use of Neuroimaging to Inform Optimal Neurocognitive Criteria for Detecting HIV-Associated Brain Abnormalities.Journal of the International Neuropsychological Society : JINS · 2020Article
- MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.NeuroImage. Clinical · 2020Article
- Longitudinal Metabolite Changes after Traumatic Brain Injury: A Prospective Pediatric Magnetic Resonance Spectroscopic Imaging Study.Journal of neurotrauma · 2019Article
- Distinguishing Brain Impact of Aging and HIV Severity in Chronic HIV Using Multiparametric MR Imaging and MR Spectroscopy.Open forum infectious diseases · 2018Article
- 7T Brain MRS in HIV Infection: Correlation with Cognitive Impairment and Performance on Neuropsychological Tests.AJNR. American journal of neuroradiology · 2018Article
- Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS.PloS one · 2018Article
- Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.Journal of neurovirology · 2014Article
- Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8-depleted rhesus macaques: proton MRS imaging at 3 T.NMR in biomedicine · 2013Article
- Imaging approaches for dementia.AJNR. American journal of neuroradiology · 2012Review
- Regional cortical thinning associated with detectable levels of HIV DNA.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations.AIDS (London, England) · 2011Article
- Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment.AIDS (London, England) · 2011Article
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Authors and funding
8 authors.
Funding
Abstract
purposeTo develop a relevant pathophysiologic model of human immunodeficiency virus (HIV)-associated dementia by studying regional variations in metabolite levels measured with magnetic resonance (MR) spectroscopic imaging and their relationship to immunologic measures and cognitive dysfunction. MATERIALS AND
methodsThis was a HIPAA-compliant, institutional review board-approved study involving written informed consent. Distributions of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr) concentrations in 94 subjects (20 seronegative controls and 74 HIV-positive subjects; 34 of the HIV-positive subjects having HIV-associated dementia; 63 men, 31 women; mean age, 40 years) were determined with proton (hydrogen 1 [(1)H]) MR spectroscopic imaging. HIV-positive subjects underwent neuropsychological testing and blood and cerebrospinal fluid (CSF) analysis. Factor analysis was utilized to determine associations between metabolites across regions. Analysis of variance and t tests were used to isolate differences between cohorts.
resultsA "Cho factor" differentiated seronegative controls from HIV-infected cohorts, indicating elevated Cho levels across deep gray and white matter regions of HIV-positive individuals. An "NAA factor" differentiated those with dementia from those without and correlated best with psychomotor and executive function tests. A "Cr factor" indicated Cr elevations correlated with CSF monocyte chemoattractant protein-1 levels. NAA and Cr factor scores were strongly weighted to metabolite changes in white matter regions.
conclusionThese results highlight the importance of white matter involvement in HIV-associated dementia and support the current pathogenesis model of glial cell proliferation in HIV infection, denoted by regional Cho elevations, and neuronal dysfunction and/or death, denoted by NAA decreases, associated with dementia. Factor analysis of MR spectroscopic imaging data is a useful method for determining regional metabolic variations in HIV infection and its neuropsychological correlates.
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