ArticleThe American journal of pathology2010
Epithelial cell apoptosis facilitates Entamoeba histolytica infection in the gut.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Cross-kingdom microbial interactions in the gut during inflammatory bowel disease.Journal of translational medicine · 2026Review
- Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption.PLoS neglected tropical diseases · 2025Article
- Gasdermins in Innate Host Defense AgainstFrontiers in immunology · 2022Review
- Association of Blastocystis ST6 with higher protease activity among symptomatic subjects.BMC microbiology · 2021Article
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- The influence of selected gastrointestinal parasites on apoptosis in intestinal epithelial cells.Biomolecules · 2020Review
- Entamoeba histolytica: Host parasite interactions at the colonic epithelium.Tissue barriers · 2017Article
- Distinct Trypanosoma cruzi isolates induce activation and apoptosis of human neutrophils.PloS one · 2017Article
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.Cellular and molecular life sciences : CMLS · 2016Review
- The effect of IFN-γ and TGF-β in the functional activity of mononuclear cells in the presence of Entamoeba histolytica.Parasites & vectors · 2015Article
- High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.BMC microbiology · 2015Article
- Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease.Frontiers in microbiology · 2015Review
- Strain-dependent induction of human enterocyte apoptosis by blastocystis disrupts epithelial barrier and ZO-1 organization in a caspase 3- and 9-dependent manner.BioMed research international · 2014Article
- In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B.Infection and immunity · 2013Article
- Globalised world, globalised diseases: A case report on an amoebiasis-associated colon perforation.World journal of clinical cases · 2013Article
- Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica.Infection and immunity · 2013Article
- The dynamic interdependence of amebiasis, innate immunity, and undernutrition.Seminars in immunopathology · 2012Review
- Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism.Infection and immunity · 2012Article
- Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.PLoS neglected tropical diseases · 2011Article
- Tissue destruction and invasion by Entamoeba histolytica.Trends in parasitology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Entamoeba histolytica is the protozoan parasite that causes amebic colitis. The parasite triggers apoptosis on contact with host cells; however, the biological significance of this event during intestinal infection is unclear. We examined the role of apoptosis in a mouse model of intestinal amebiasis. Histopathology revealed that abundant epithelial cell apoptosis occurred in the vicinity of amoeba in histological specimens. Epithelial cell apoptosis occurred rapidly on co-culture with amoeba in vitro as measured by annexin positivity, DNA degradation, and mitochondrial dysfunction. Administration of the pan caspase inhibitor ZVAD decreased the rate and severity of amebic infection in CBA mice by all measures (cecal culture positivity, parasite enzyme-linked immunosorbent assay, and histological scores). Similarly, caspase 3 knockout mice on the resistant C57BL/6 background exhibited even lower cecal parasite antigen burden and culture positive rates than wild type mice. The permissive effect of apoptosis on infection could be tracked to the epithelium, in that transgenic mice that overexpressed Bcl-2 in epithelial cells were more resistant to infection as measured by cecal parasite enzyme-linked immunosorbent assay and histological scores. We concluded that epithelial cell apoptosis in the intestine facilitates amebic infection in this mouse model. The parasite's strategy for inducing apoptosis may point to key virulence factors, and therapeutic maneuvers to diminish epithelial apoptosis may be useful in amebic colitis.
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Registered trials
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