Evidence map›Paper›PMID 20093089›Full record

ArticleReproductive biomedicine online2010

Long-distance transportation of primate embryos developing in culture: a preliminary study.

Stephanie Nichols, Alexandra Harvey, Lynette Gierbolini, Janis Gonzalez-Martinez, Carol Brenner, Barry Bavister

Open access · bronzeAbstract read
In one paragraph

Article in Reproductive biomedicine online, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Stephanie NicholsCaribbean Primate Research Center, University of Puerto Rico, Sabana Seca, PR 00952, Puerto Rico. stephanie.nichols@upr.edu
Alexandra Harvey
Lynette Gierbolini
Janis Gonzalez-Martinez
Carol Brenner
Barry Bavister
University of Puerto Rico System · PRWayne State University · US

Funding

Translational Research at the CPRC:genetic model of primate circadian disorderP40RR003640 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI KRAISELBURD, EDMUNDO NELSON · 1987 to 2011
$21.1M
EMBRYO TECHNOLOGIES FOR PROPAGATION OF RHESUS MONKEYSR24RR015395 · NCRR · WAYNE STATE UNIVERSITY · PI BAVISTER, BARRY DOUGLAS · 2002 to 2006
$1.4M
Characterization of Monkey Embryonic Stem CellsR21RR021881 · NCRR · WAYNE STATE UNIVERSITY · PI BRENNER, CAROL · 2005 to 2007
$578k
Chromosomal anomalies in macaque monkey oocytesR03HD046553 · NICHD · WAYNE STATE UNIVERSITY · PI BRENNER, CAROL · 2005 to 2006
$205k
NCRR NIH HHS 5R24RR015395NCRR NIH HHS P40 RR003640NCRR NIH HHS R21 RR021881NCRR NIH HHS R24 RR015395NCRR NIH HHS RR003640NICHD NIH HHS R03 HD046553
6 · The paper itself

Abstract

Non-human primate embryos are invaluable for conducting research relevant to human infertility and stem cells, but their availability is restricted. In this preliminary study, rhesus monkey embryos were produced by IVF at the Caribbean Primate Research Centre and shipped in tubes of gassed culture medium within a battery-powered transport incubator by overnight courier to Wayne State University in Michigan. Upon arrival, the embryos were incubated in fresh culture medium to evaluate further development. In 11 shipments comprising 98 cleavage-stage embryos developing from oocytes that were mature (MII) upon collection, 51 (52%) reached advanced preimplantation stages (morula to hatched blastocyst) during prolonged culture following transportation. However, most embryos produced from oocytes that were immature (MI) at collection arrested and only 5/51 (10%) reached advanced stages of development. This study demonstrates that non-cryopreserved primate embryos can be routinely transported between distant sites without loss of developmental ability. In this way, the processes of production and study of non-cryopreserved primate embryos need not be restricted to the same or nearby laboratories. This will expand the use of these embryos for research and facilitate generation of translationally relevant information.

Indexed as

Embryo, MammalianTransportationAnimalsEmbryo Culture TechniquesEmbryonic DevelopmentFertilization in VitroMacaca mulattaMichiganPuerto Rico

Identifiers

PMID20093089
PMCPMC2829350
OpenAlexW1980665374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.