ArticleThe Journal of nutritional biochemistry2010
Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides.
Article in The Journal of nutritional biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Exploring the Link Between Vitamin K and Depression: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The long-acting anticoagulant rodenticide brodifacoum induces neuropathology in adult New Zealand White rabbits and is reduced by the bile sequestrant cholestyramine.Neurotoxicology · 2026Article
- The epigenetic potential of vitamin K2 in brain health.Epigenomics · 2025Review
- Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts.NPJ biofilms and microbiomes · 2025Article
- Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation.Antioxidants (Basel, Switzerland) · 2024Review
- The biological responses of vitamin K2: A comprehensive review.Food science & nutrition · 2023Review
- Vitamin K2 in multiple sclerosis patients.Wiener klinische Wochenschrift · 2018Article
- Article
- Vitamin Supplementation as an Adjuvant Treatment for Alzheimer's Disease.Journal of clinical and diagnostic research : JCDR · 2016Review
- The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures.Annals of the New York Academy of Sciences · 2016Review
- The Role of 3-O-Sulfogalactosylceramide, Sulfatide, in the Lateral Organization of Myelin Membrane.Neurochemical research · 2016Review
- The challenge of understanding cerebral white matter injury in the premature infant.Neuroscience · 2014Review
- Vitamin K and the nervous system: an overview of its actions.Advances in nutrition (Bethesda, Md.) · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dysregulation of myelin sulfatides is a risk factor for cognitive decline with age. Vitamin K is present in high concentrations in the brain and has been implicated in the regulation of sulfatide metabolism. Our objective was to investigate the age-related interrelation between dietary vitamin K and sulfatides in myelin fractions isolated from the brain regions of Fischer 344 male rats fed one of two dietary forms of vitamin K: phylloquinone or its hydrogenated form, 2',3'-dihydrophylloquinone (dK), for 28 days. Both dietary forms of vitamin K were converted to menaquinone-4 (MK-4) in the brain. The efficiency of dietary dK conversion to MK-4 compared to dietary phylloquinone was lower in the striatum and cortex, and was similar to that in the hippocampus. There were significant positive correlations between sulfatides and MK-4 in the hippocampus (phylloquinone-supplemented diet, 12 and 24 months; dK-supplemented diet, 12 months) and cortex (phylloquinone-supplemented diet, 12 and 24 months). No significant correlations were observed in the striatum. Furthermore, sulfatides in the hippocampus were significantly positively correlated with MK-4 in serum. This is the first attempt to establish and characterize a novel animal model that exploits the inability of dietary dK to convert to brain MK-4 to study the dietary effects of vitamin K on brain sulfatide in brain regions controlling motor and cognitive functions. Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure and behavior functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.