Evidence map›Paper›PMID 20092966›Full record

Trial reportDrug and alcohol dependence2010

Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependence.

Keith G Heinzerling, Aimee-Noelle Swanson, Soeun Kim, Lisa Cederblom, Ardis Moe, Walter Ling, Steven Shoptaw

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00469508 (A Randomized, Double-Blind, Placebo-Controlled Evaluation of Modafinil vs Placebo for the Treatment of Methamphetamine Dependence), which is not on this map. Cited by 65 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 7 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00469508 phase2completednot on this map

A Randomized, Double-Blind, Placebo-Controlled Evaluation of Modafinil vs Placebo for the Treatment of Methamphetamine Dependence

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2009Enrolled71ConditionsMethamphetamine DependenceArmsModafinil, Placebo
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Efficacy of psychostimulant drugs for amphetamine abuse or dependence.The Cochrane database of systematic reviews · 2013
    Pooled it
  7. Guideline
  8. Randomized, Placebo-Controlled Trial of Targeting Neuroinflammation with Ibudilast to Treat Methamphetamine Use Disorder.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Trial
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  10. Sustained-release methylphenidate in methamphetamine dependence treatment: a double-blind and placebo-controlled trial.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015
    Trial
  11. Trial
  12. Trial
  13. Trial
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  17. Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Trial
  18. Trial
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  20. Trial

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Keith G HeinzerlingDepartment of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. KHeinzerling@mednet.ucla.edu
Aimee-Noelle Swanson
Soeun Kim
Lisa Cederblom
Ardis Moe
Walter Ling
Steven Shoptaw
University of California, Los Angeles · USNeurobehavioral Systems · US

Funding

UCLA Medication Development Unit for Stimulant AbuseP50DA018185 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHOPTAW, STEVEN J · 2004 to 2009
$5.8M
Pharmacogenomics and Medication Development for Methamphetamine DependenceK23DA023558 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEINZERLING, KEITH GREGORY · 2008 to 2012
$848k
NIDA NIH HHS 1 K23 DA 023558NIDA NIH HHS 1 P50 DA18185NIDA NIH HHS K23 DA023558NIDA NIH HHS P50 DA018185
6 · The paper itself

Abstract

objectiveTo compare modafinil to placebo for reducing methamphetamine (MA) use, improving retention, and reducing depressive symptoms and MA cravings. Rates of adverse events and cigarette smoking with modafinil versus placebo were also compared.

methodsFollowing a 2-week, non-medication lead-in period, 71 treatment-seeking MA-dependent participants were randomly assigned to modafinil (400mg once daily; N=34) or placebo (once daily; N=37) for 12 weeks under double-blind conditions. Participants attended clinic thrice-weekly to provide urine samples analyzed for MA-metabolite, to complete research assessments, and to receive contingency management and weekly cognitive behavioral therapy (CBT) sessions.

resultsThere were no statistically significant effects for modafinil on MA use, retention, depressive symptoms, or MA cravings in pre-planned analyses. Outcomes for retention and MA use favored modafinil in a post hoc analysis among participants with low CBT attendance and among participants with baseline high-frequency of MA use (MA use on >18 of past 30 days), but did not reach statistical significance in these small subgroups. Modafinil was safe and well tolerated and did not increase cigarette smoking.

conclusionsModafinil was no more effective than placebo at 400mg daily in a general sample of MA users. A post hoc analysis showing a trend favoring modafinil among subgroups with baseline high-frequency MA use and low CBT attendance suggests that further evaluation of modafinil in MA users is warranted.

Indexed as

MethamphetamineAdolescentAdultAmphetamine-Related DisordersBenzhydryl CompoundsCentral Nervous System StimulantsCognitive Behavioral TherapyCounselingData Interpretation, StatisticalDepressive DisorderDouble-Blind MethodFemaleHumansMaleModafinilPatient ComplianceBenzhydryl CompoundsCentral Nervous System StimulantsMethamphetamineModafinil

Identifiers

PMID20092966
PMCPMC2875545
OpenAlexW2033658202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.