ReviewRespiratory research2010
Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One.
Review in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Pooled it
- A Systematic Review of the Prevalence of Atopic Diseases in Children on the Arabian Peninsula.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Pooled it
- Association between rhinovirus wheezing illness and the development of childhood asthma: a meta-analysis.BMJ open · 2017Pooled it
- Topical tacrolimus for atopic dermatitis.The Cochrane database of systematic reviews · 2015Pooled it
- Pooled it
- Atopic dermatitis and indoor use of energy sources in cooking and heating appliances.BMC public health · 2012Trial
- Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Sun Exposure and Asthma Prevalence in Spanish Schoolchildren and Adolescents in the Global Asthma Network (GAN) Phase I Study: A Semi-Individual Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Prediction of future onset of allergic rhinitis and analysis of risk factors in children with food allergy during infancy.European journal of pediatrics · 2026Article
- Early-life exposure to residential greenness and risk of asthma in a U.S. bronchiolitis cohort.Allergy · 2024Article
- Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review.International journal of environmental research and public health · 2023Review
- The Effects of Short-Term PMInternational journal of environmental research and public health · 2022Article
- Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study.Environmental health : a global access science source · 2022Article
- The Role of PPAR-γ in Allergic Disease.Current allergy and asthma reports · 2021Review
- Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch.JAMA dermatology · 2021Article
- The Role of the Environment and Exposome in Atopic Dermatitis.Current treatment options in allergy · 2021Review
- A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia.The World Allergy Organization journal · 2020Review
- Understanding the dynamics of asthma symptoms between childhood and adolescence using latent transition analysis.International journal of public health · 2020Article
- Grand Challenges in Rhinology.Frontiers in allergy · 2020Article
- The exposome in atopic dermatitis.Allergy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here.In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution.Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence.The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.
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